Contact +351 259 350 475

Carlos Alexandre Martins Gomes Scholarship Researcher

BIO

Name: Carlos Alexandre Martins Gomes

Aggregation: Scholarship Researcher

Orcid ID: 0000-0002-1564-3661

Email: gomes.ma.carlos@gmail.com

URL:

Phone:

Research Tasks

Innovative technologies and processes

Valorisation of bio-based products and and co-products

Resume

Publications

Chemical Characterization and Bioactivity of Extracts from Thymus mastichina: A Thymus with a Distinct Salvianolic Acid Composition.
Taghouti, Meriem; Martins-Gomes, Carlos; Schafer, Judith; Santos, João A.; Bunzel, Mirko; Nunes, Fernando M.; Silva, Amélia M. (2020) Chemical Characterization and Bioactivity of Extracts from Thymus mastichina: A Thymus with a Distinct Salvianolic Acid Composition. ANTIOXIDANTS 9 :34. doi: 10.3390/antiox9010034. (Impact factor, Quartile: 5.014, Q1).
Diabetic retinopathy and ocular melanoma: How far we are?
Souto, E.B.; Campos, J.R.; da Ana, R.; Fangueiro, J.F.; Martins-Gomes, C.; Durazzo, A.; Lucarini, M.; Sánchez-López, E.; Espina, M.; García, M.L.; Silva, A.M.; Mendonça, F.; Santini, A.; Souto, S.B. (2020) Diabetic retinopathy and ocular melanoma: How far we are? APPLIED SCIENCES 10 (8) :2777. doi: 10.3390/APP10082777. (Impact factor, Quartile: 2.474, Q2).
Nanomaterials for skin delivery of cosmeceuticals and pharmaceuticals.
Souto, E.B.; Fernandes, A.R.; Martins-Gomes, C.; Coutinho, T.E.; Durazzo, A.; Lucarini, M.; Souto, S.B.; Silva, A.M.; Santini, A. (2020) Nanomaterials for skin delivery of cosmeceuticals and pharmaceuticals. APPLIED SCIENCES 10 (5) :1594. doi: 10.3390/app10051594. (Impact factor, Quartile: 2.474, Q2).
Ocular cell lines and genotoxicity assessment.
Souto, E.B.; Campos, J.R.; Da Ana, R.; Martins-Gomes, C.; Silva, A.M.; Souto, S.B.; Lucarini, M.; Durazzo, A.; Santini, A. (2020) Ocular cell lines and genotoxicity assessment. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 17 (6) :2046. doi: 10.3390/ijerph17062046. (Impact factor, Quartile: 2.849, Q2).
Polyphenol composition and biological activity of Thymus citriodorus and Thymus vulgaris: Comparison with endemic Iberian Thymus species.
Taghouti, M.; Martins-Gomes, C.; Félix, L.M.; Schäfer, J.; Santos, J.A.; Bunzel, M.; Nunes, F.M.; Silva, A.M. (2020) Polyphenol composition and biological activity of Thymus citriodorus and Thymus vulgaris: Comparison with endemic Iberian Thymus species. FOOD CHEMISTRY 331 :127362. doi: 10.1016/j.foodchem.2020.127362. (Impact factor, Quartile: 6.306, Q1).
Thymus zygis subsp. zygis an Endemic Portuguese Plant: Phytochemical Profiling, Antioxidant, Anti-Proliferative and Anti-Inflammatory Activities.
Silva, Amélia M.; Martins-Gomes, Carlos; Souto, Eliana B.; Schafer, Judith; Santos, João A.; Bunzel, Mirko; Nunes, Fernando M. (2020) Thymus zygis subsp. zygis an Endemic Portuguese Plant: Phytochemical Profiling, Antioxidant, Anti-Proliferative and Anti-Inflammatory Activities. ANTIOXIDANTS 9 :482. doi: 10.3390/antiox9060482. (Impact factor, Quartile: 5.014, Q1).
3D Printing in the Design of Pharmaceutical Dosage Forms.
Souto, E.B.; Campos, J.R.; Filho, S.C.; Teixeira, M.C.; Martins-Gomes, C.; Zielinska, A.; Carbone, C.; Silva, A.M. (2019) 3D Printing in the Design of Pharmaceutical Dosage Forms. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY 24 (8) :1044-1053. doi: 10.1080/10837450.2019.1630426. (Impact factor, Quartile: 2.347, Q2).
Clotrimazole-loaded Mediterranean Essential Oils NLC: a synergic treatment of Candida Skin Infections.
Carbone, Claudia; Teixeira, Maria do Céu; Sousa, Maria do Céu; Martins-Gomes, Carlos; Silva, Amélia M.; Souto, Eliana B.; Musumeci, Teresa (2019) Clotrimazole-loaded Mediterranean Essential Oils NLC: a synergic treatment of Candida Skin Infections. PHARMACEUTICS 11 (5) :231. doi: 10.3390/pharmaceutics11050231. (Impact factor, Quartile: 4.773, Q1).
Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines.
Silva, Amélia M.; Martins-Gomes, Carlos; Fangueiro, Joana F.; Andreani, Tatiana; Souto, Eliana B. (2019) Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY 24 (10) :1243-1249. doi: 10.1080/10837450.2019.1658774. (Impact factor, Quartile: 2.347, Q2).
Ginkgo biloba L. Leaf Extract Protects HepG2 Cells Against Paraquat-Induced Oxidative DNA Damage.
Silva, Amélia M.; Silva, Sandra C.; Soares, Jorge P., Martins-Gomes, Carlos; Teixeira, João P.; Leal, Fernanda; Gaivão, Isabel (2019) Ginkgo biloba L. Leaf Extract Protects HepG2 Cells Against Paraquat-Induced Oxidative DNA Damage. PLANTS 8 (12) :556. doi: 10.3390/plants8120556. (Impact factor, Quartile: 2.632, Q1).
In vitro cytotoxicity of oleanolic/ursolic acids-loaded in PLGA nanoparticles in different cell lines.
Silva, Amélia M.; Alvarado, Helen L.; Abrego, Gaudalupe; Martins-Gomes, Carlos; Garduño-Ramirez, Maria L.; García, Maria L.; Calpena, Ana C.; Souto, Eliana B. (2019) In vitro cytotoxicity of oleanolic/ursolic acids-loaded in PLGA nanoparticles in different cell lines. PHARMACEUTICS 11 (8) :362. doi: 10.3390/pharmaceutics11080362. (Impact factor, Quartile: 4.773, Q1).
Myasthenia Gravis: State of the art and new therapeutic strategies.
Souto, Eliana B.; Lima, Bernardo; Campos, Joana; Martins Gomes, Carlos; Souto, Selma B.; Silva, Amelia M. (2019) Myasthenia Gravis: State of the art and new therapeutic strategies. JOURNAL OF NEUROIMMUNOLOGY 337 :577080. doi: 10.1016/j.jneuroim.2019.577080. (Impact factor, Quartile: 2.832, Q2).
Polyphenols for Skin Cancer: Chemical Properties, Structure-Related Mechanisms of Action and New Delivery Systems.
Souto, Eliana B.; Sampaio, Ana C.; Campos, Joana; Martins-Gomes, Carlos; Aires, Alfredo; Silva, Amélia M. (2019) Polyphenols for Skin Cancer: Chemical Properties, Structure-Related Mechanisms of Action and New Delivery Systems. In: Atta-ur-Rahman (Ed). Studies in Natural Products Chemistry - Bioactive Natural Products. Elsevier Science Publishers, Amsterdam, the Netherlands. 63 (Chapter 2) :21-42. ISBN: 9780128179017. doi: 10.1016/B978-0-12-817901-7.00002-2.
Rosmarinic Acid: Sources, Bioactivities and Health Benefits.
Martins-Gomes, Carlos; Nunes, Fernando M.; Sampaio, Ana C.; Souto, Eliana B.; Silva, Amélia M. (2019) Rosmarinic Acid: Sources, Bioactivities and Health Benefits. IN: Ryan, Iman (Ed.) Phytochemicals: Plant Sources and Potential Health Benefits. Book Series: Plant Science Research and Practices. NovaScience Publishers, New York, USA (Chapter 4) :109-146. ISBN: 978-1-53615-478-8.
The influence of polysaccharide coating on the physicochemical parameters and cytotoxicity of silica nanoparticles for hydrophilic biomolecules delivery.
Andreani, Tatiana; Fangueiro, Joana F.; Severino, Patrícia; Souza, Ana L.; Martins-Gomes, Carlos; Fernandes, Paulo M.; Calpena, Ana C.; Gremião, Maria P.; Souto, Eliana B.; Silva, Amélia M. (2019) The influence of polysaccharide coating on the physicochemical parameters and cytotoxicity of silica nanoparticles for hydrophilic biomolecules delivery. NANOMATERIALS 9 (8) :1081. doi: 10.3390/nano9081081. (Impact factor, Quartile: 4.034, Q1).
Thymus carnosus extracts induce anti-proliferative activity in Caco-2 cells through mechanisms that involve cell cycle arrest and apoptosis.
Martins-Gomes, Carlos; Souto, Eliana B.; Cosme, Fernanda; Nunes, Fernando M.; Silva, Amélia M. (2019) Thymus carnosus extracts induce anti-proliferative activity in Caco-2 cells through mechanisms that involve cell cycle arrest and apoptosis. JOURNAL OF FUNCTIONAL FOODS 54 :128-135. doi: 10.1016/j.jff.2019.01.010. (Impact factor, Quartile: 3.197, Q1).
Trends in Atopic Dermatitis - from standard pharmacotherapy to novel drug delivery systems.
Souto, Eliana B.; Dias-Ferreira, João; Oliveira, Jessica; Sanchez-Lopez, Elena; Lopez-Machado, Ana; Espina, Marta; Garcia, Maria Luisa; Souto, Selma B.; Martins-Gomes, Carlos; Silva, Amélia M. (2019) Trends in Atopic Dermatitis - from standard pharmacotherapy to novel drug delivery systems. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20 (22) :5659. doi: 10.3390/ijms20225659. (Impact factor, Quartile: 4.183, Q1).
Uveal melanoma: physiopathology and new in situ-specific therapies.
Souto, E.B.; Zielinska, A.; Luis, M.; Carbone, C.; Martins-Gomes, C.; Souto, S.B.; Silva, A.M. (2019) Uveal melanoma: physiopathology and new in situ-specific therapies. CANCER CHEMOTHERAPY AND PHARMACOLOGY 84 (1) :15-32. doi: 10.1007/s00280-019-03860-z. (Impact factor, Quartile: 3.008, Q1).
Anti-inflammatory and Anti-cancer Activity of Citral: Optimization of Citral-loaded Solid Lipid Nanoparticles (SLN) using Experimental Factorial Design and LUMiSizer.
Zielińska, Alexandra; Martins-Gomes, Carlos; Ferreira, Nuno R. ; Silva, Amélia M.; Nowak, I.; Souto, Eliana B. (2018) Anti-inflammatory and Anti-cancer Activity of Citral: Optimization of Citral-loaded Solid Lipid Nanoparticles (SLN) using Experimental Factorial Design and LUMiSizer. INTERNATIONAL JOURNAL OF PHARMACEUTICS 553 (2-Jan) :428-440. doi: 10.1016/j.ijpharm.2018.10.065. (Impact factor, Quartile: 3.862, Q1).
Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss.
Martins-Gomes, Carlos; Taghouti, Meriem; Schaefer, Judith; Bunzel, Mirko; Silva, Amelia M.; Nunes, Fernando M. (2018) Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss. Journal Of Functional Foods 43 :154-164. doi: 10.1016/j.jff.2018.02.012. (Impact factor, Quartile: 3.47, Q1).
Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles.
Carbone, C.; Martins-Gomes, C.; Caddeo, C.; Silva, A. M.; Musumeci, T.; Pignatello, R.; Puglisi, G.; Souto, E. B. (2018) Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles. International Journal Of Pharmaceutics 548 (1) :217-226. doi: 10.1016/j.ijpharm.2018.06.064. (Impact factor, Quartile: 3.862, Q1).
Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy.
Carbone, C.; Martins-Gomes, C.; Pepe, V.; Silva, A. M.; Musumeci, T.; Puglisi, G.; Furneri, P. M.; Souto, E. B. (2018) Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy. Colloids And Surfaces B-Biointerfaces 167 :337-344. doi: 10.1016/j.colsurfb.2018.04.031. (Impact factor, Quartile: 3.997, Q1).
Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds.
Taghouti, Meriem; Martins-Gomes, Carlos; Schaefer, Judith; Felix, Luis M.; Santos, Joao A.; Bunzel, Mirko; Nunes, Fernando M.; Silva, Amelia M. (2018) Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds. Food & Function 9 (7) :3617-3629. doi: 10.1039/c8fo00456k. (Impact factor, Quartile: 3.289, Q1).
Soft Cationic Nanoparticles for Drug Delivery: Production and Cytotoxicity of Solid Lipid Nanoparticles (SLN).
Silva, Amélia M.; Martins-Gomes, Carlos; Coutinho, Tiago E.; Fangueiro, Joana F.; Sanchez-Lopez, E.; Pashirova, Tatiana N.; Souto, Eliana B. Soft Cationic Nanoparticles for Drug Delivery: Production and Cytotoxicity of Solid Lipid Nanoparticles (SLN). APPLIED SCIENCES 9 (20) :4438. doi: 10.3390/app9204438. (Impact factor, Quartile: 2.217, Q1).