Amélia Maria Lopes Dias da Silva Integrated Member

BIO

Name: Amélia Maria Lopes Dias da Silva

Aggregation: Integrated Member

Scopus author ID: 35578752300

Orcid ID: 0000-0002-7524-9914

Ciência Vitae: 241E-3956-0242

Email: amsilva@utad.pt

Publications

From cultural and natural heritage to reservoir of biomedicine: Prospection of bioactive compounds produced by bacterial isolates from caves
Gatinho P., Salvador C., Gutierrez-Patricio S., Macedo-Arantes S., Martins M.R., Silva A.M., Miller A.Z., Caldeira A.T., (2024) From cultural and natural heritage to reservoir of biomedicine: Prospection of bioactive compounds produced by bacterial isolates from caves International Biodeterioration and Biodegradation 190 (105773). doi: 10.1016/j.ibiod.2024.105773.

Hibiscus sabdariffa-loaded nanostructured lipid carriers (NLC) for fortified nutraceutical milks
Pimentel-Moral S., Durazzo A., Lucarini M., Fernández-Ochoa Á., de la Luz Cádiz-Gurrea M., Arráez-Román D., Silva A.M., Santini A., Fonseca J., Segura-Carretero A., Souto E.B., (2024) Hibiscus sabdariffa-loaded nanostructured lipid carriers (NLC) for fortified nutraceutical milks European Food Research and Technology 250 :1999-2010. ISSN: 14382385. doi: 10.1007/s00217-024-04509-9.

Labdanum Resin from Cistus ladanifer L. as a Source of Compounds with Anti-Diabetic, Neuroprotective and Anti-Proliferative Activity
Frazão D.F., Martins-Gomes C., Díaz T.S., Delgado F., Gonçalves J.C., Silva A.M., (2024) Labdanum Resin from Cistus ladanifer L. as a Source of Compounds with Anti-Diabetic, Neuroprotective and Anti-Proliferative Activity Molecules 29 (2222). ISSN: 14203049. doi: 10.3390/molecules29102222.

Linking Variability in Phytochemical Composition with Safety Profile of Thymus carnosus Boiss. Extracts: Effect of Major Compounds and Evaluation of Markers of Oxidative Stress and Cell Death
Martins-Gomes C., Nunes F.M., Silva A.M., (2024) Linking Variability in Phytochemical Composition with Safety Profile of Thymus carnosus Boiss. Extracts: Effect of Major Compounds and Evaluation of Markers of Oxidative Stress and Cell Death International Journal of Molecular Sciences 25 (5343). ISSN: 14220067. doi: 10.3390/ijms25105343.

Biopharmaceutical applications of Opuntia ficus-indica: bibliometric map, bioactivities and extraction techniques
Guedes B.N., Fathi F., Silva A.M., Santini A., Oliveira M.B.P.P., Souto E.B., (2023) Biopharmaceutical applications of Opuntia ficus-indica: bibliometric map, bioactivities and extraction techniques European Food Research and Technology 249 :2457-2469. ISSN: 14382385. doi: 10.1007/s00217-023-04314-w.

Cell penetrating peptides-functionalized Licochalcone-A-loaded PLGA nanoparticles for ocular inflammatory diseases: Evaluation of in vitro anti-proliferative effects, stabilization by freeze-drying and characterization of an in-situ forming gel
Galindo-Camacho R.M., Haro I., Gómara M.J., Espina M., Fonseca J., Martins-Gomes C., Camins A., Silva A.M., García M.L., Souto E.B., (2023) Cell penetrating peptides-functionalized Licochalcone-A-loaded PLGA nanoparticles for ocular inflammatory diseases: Evaluation of in vitro anti-proliferative effects, stabilization by freeze-drying and characterization of an in-situ forming gel International Journal of Pharmaceutics 639 (122982). ISSN: 18733476. doi: 10.1016/j.ijpharm.2023.122982.

Effect of cultivar, maturation stage, and year on sugar and phenolic composition of elderberries
Ferreira S.S., Silva P., Silva A.M., Nunes F.M., (2023) Effect of cultivar, maturation stage, and year on sugar and phenolic composition of elderberries Journal of the Science of Food and Agriculture 103 :2023-2036. ISSN: 10970010. doi: 10.1002/jsfa.12271.

Modified Drug Delivery Systems for Veterinary Use: Pharmaceutical Development and Applications
Souto E.B., Barbosa C.I., Baldim I., Campos J.R., Fernandes A.R., Mazzola P.G., Andreani T., Dias I.R., Durazzo A., Lucarini M., Atanasov A.G., Silva A.M., Santini A., (2023) Modified Drug Delivery Systems for Veterinary Use: Pharmaceutical Development and Applications Current Bioactive Compounds 19 (e040422203061) :69-76. ISSN: 18756646. doi: 10.2174/1573407218666220404110837.

Modulation of Cell Death Pathways for Cellular Protection and Anti-Tumoral Activity: The Role of Thymus spp. Extracts and Their Bioactive Molecules
Martins-Gomes C., Nunes F.M., Silva A.M., (2023) Modulation of Cell Death Pathways for Cellular Protection and Anti-Tumoral Activity: The Role of Thymus spp. Extracts and Their Bioactive Molecules International Journal of Molecular Sciences 24 (1691). ISSN: 14220067. doi: 10.3390/ijms24021691.

Molecular Characterization of Prunus lusitanica L. Fruit Extracts and Their Health-Promoting Potential in Inflammation, Diabetes, and Neurodegenerative Diseases
Abraão A., Martins-Gomes C., Domínguez-Perles R., Barros A., Silva A.M., (2023) Molecular Characterization of Prunus lusitanica L. Fruit Extracts and Their Health-Promoting Potential in Inflammation, Diabetes, and Neurodegenerative Diseases International Journal of Molecular Sciences 24 (8830). ISSN: 14220067. doi: 10.3390/ijms24108830.

Natural Products as a Tool to Modulate the Activity and Expression of Multidrug Resistance Proteins of Intestinal Barrier
Martins-Gomes C., Silva A.M., (2023) Natural Products as a Tool to Modulate the Activity and Expression of Multidrug Resistance Proteins of Intestinal Barrier Journal of Xenobiotics 13 :172-192. ISSN: 20394713. doi: 10.3390/jox13020014.

Phytochemical Composition and Antioxidant, Anti-Acetylcholinesterase, and Anti-α-Glucosidase Activity of Thymus carnosus Extracts: A Three-Year Study on the Impact of Annual Variation and Geographic Location
Martins-Gomes C., Steck J., Keller J., Bunzel M., Santos J.A., Nunes F.M., Silva A.M., (2023) Phytochemical Composition and Antioxidant, Anti-Acetylcholinesterase, and Anti-α-Glucosidase Activity of Thymus carnosus Extracts: A Three-Year Study on the Impact of Annual Variation and Geographic Location Antioxidants 12 (668). ISSN: 20763921. doi: 10.3390/antiox12030668.

Prokaryotic Communities from Pristine Cave Environments: Biotechnological Potential with Sustainable Production
Gatinho P., Salvador C., Silva A.M., Caldeira A.T., (2023) Prokaryotic Communities from Pristine Cave Environments: Biotechnological Potential with Sustainable Production Sustainability (Switzerland) 15 (7471). ISSN: 20711050. doi: 10.3390/su15097471.

Prunus lusitanica L. Fruits: A Promising Underexploited Source of Nutrients with Potential Economic Value
Abraão A., Yu M., Gouvinhas I., Ferreira L., Silva A.M., Domínguez-Perles R., Barros A., (2023) Prunus lusitanica L. Fruits: A Promising Underexploited Source of Nutrients with Potential Economic Value Foods 12 (973). ISSN: 23048158. doi: 10.3390/foods12050973.

Rockrose Land Management: Contribution of Periodic Harvesting to Increase Value and to Control Cistus ladanifer L. Shrublands
Frazão D.F., Gonçalves J.C., Silva A.M., Delgado F., (2023) Rockrose Land Management: Contribution of Periodic Harvesting to Increase Value and to Control Cistus ladanifer L. Shrublands Forests 14 (638). ISSN: 19994907. doi: 10.3390/f14030638.

Applications of nanotechnology in chronic diseases and tissue regeneration
Formoso I., Shegokar R., Zielinska A., Silva A.M., Souto E.B., (2022) Applications of nanotechnology in chronic diseases and tissue regeneration Nanotechnology and Regenerative Medicine: History, Techniques, Frontiers, and Applications :507-527. doi: 10.1016/B978-0-323-90471-1.00021-9.

Chemical Composition and Potential Biological Activity of Melanoidins From Instant Soluble Coffee and Instant Soluble Barley: A Comparative Study
Antonietti S., Silva A.M., Simões C., Almeida D., Félix L.M., Papetti A., Nunes F.M., (2022) Chemical Composition and Potential Biological Activity of Melanoidins From Instant Soluble Coffee and Instant Soluble Barley: A Comparative Study Frontiers in Nutrition 9 (825584). ISSN: 2296861X. doi: 10.3389/fnut.2022.825584.

Customized cationic nanoemulsions loading triamcinolone acetonide for corneal neovascularization secondary to inflammatory processes
Fernandes A.R., Vidal L.B., Sánchez-López E., dos Santos T., Granja P.L., Silva A.M., Garcia M.L., Souto E.B., (2022) Customized cationic nanoemulsions loading triamcinolone acetonide for corneal neovascularization secondary to inflammatory processes International Journal of Pharmaceutics 623 (121938). ISSN: 18733476. doi: 10.1016/j.ijpharm.2022.121938.

Elderberry (Sambucus nigra L.) extracts promote anti-inflammatory and cellular antioxidant activity
Ferreira S.S., Martins-Gomes C., Nunes F.M., Silva A.M., (2022) Elderberry (Sambucus nigra L.) extracts promote anti-inflammatory and cellular antioxidant activity Food Chemistry: X 15 (100437). ISSN: 25901575. doi: 10.1016/j.fochx.2022.100437.

Exudative versus Nonexudative Age-Related Macular Degeneration: Physiopathology and Treatment Options
Fernandes A.R., Zielińska A., Sanchez-Lopez E., Dos Santos T., Garcia M.L., Silva A.M., Karczewski J., Souto E.B., (2022) Exudative versus Nonexudative Age-Related Macular Degeneration: Physiopathology and Treatment Options International Journal of Molecular Sciences 23 (2592). ISSN: 14220067. doi: 10.3390/ijms23052592.

Glyphosate vs. Glyphosate-Based Herbicides Exposure: A Review on Their Toxicity
Martins-Gomes C., Silva T.L., Andreani T., Silva A.M., (2022) Glyphosate vs. Glyphosate-Based Herbicides Exposure: A Review on Their Toxicity Journal of Xenobiotics 12 :21-40. ISSN: 20394713. doi: 10.3390/jox12010003.

Hydrogels for Modified-release Drug Delivery Systems
Zielińska A., Eder P., Rannier L., Cardoso J.C., Severino P., Silva A.M., Souto E.B., (2022) Hydrogels for Modified-release Drug Delivery Systems Current Pharmaceutical Design 28 :609-618. ISSN: 18734286. doi: 10.2174/1381612828666211230114755.

In Vitro Assessment of Pesticides Toxicity and Data Correlation with Pesticides Physicochemical Properties for Prediction of Toxicity in Gastrointestinal and Skin Contact Exposure
Silva A.M., Martins-Gomes C., Silva T.L., Coutinho T.E., Souto E.B., Andreani T., (2022) In Vitro Assessment of Pesticides Toxicity and Data Correlation with Pesticides Physicochemical Properties for Prediction of Toxicity in Gastrointestinal and Skin Contact Exposure Toxics 10 (378). ISSN: 23056304. doi: 10.3390/toxics10070378.

Labdanum Resin from Cistus ladanifer L.: A Natural and Sustainable Ingredient for Skin Care Cosmetics with Relevant Cosmeceutical Bioactivities
Frazão D.F., Martins-Gomes C., Steck J.L., Keller J., Delgado F., Gonçalves J.C., Bunzel M., Pintado C.M.B.S., Díaz T.S., Silva A.M., (2022) Labdanum Resin from Cistus ladanifer L.: A Natural and Sustainable Ingredient for Skin Care Cosmetics with Relevant Cosmeceutical Bioactivities Plants 11 (1477). ISSN: 22237747. doi: 10.3390/plants11111477.

Lipid nanoparticles-based semisolid formulations for cosmetic applications: focus on cellulite
Silva A.M., Cruz A.T., Nobre J., Coutinho T.E., Cano A., Zielinska A., Kovačević A., Severino P., Souto E.B., (2022) Lipid nanoparticles-based semisolid formulations for cosmetic applications: focus on cellulite Nanotechnology and Regenerative Medicine: History, Techniques, Frontiers, and Applications :179-193. doi: 10.1016/B978-0-323-90471-1.00014-1.

Lipid-Based Nanoparticulate Systems for the Ocular Delivery of Bioactives with Anti-Inflammatory Properties
Ana R.d., Fonseca J., Karczewski J., Silva A.M., Zielińska A., Souto E.B., (2022) Lipid-Based Nanoparticulate Systems for the Ocular Delivery of Bioactives with Anti-Inflammatory Properties International Journal of Molecular Sciences 23 (12102). ISSN: 14220067. doi: 10.3390/ijms232012102.

Lipid-Drug Conjugates and Nanoparticles for the Cutaneous Delivery of Cannabidiol
Zielińska A., Cano A., Andreani T., Martins-Gomes C., Silva A.M., Szalata M., Słomski R., Souto E.B., (2022) Lipid-Drug Conjugates and Nanoparticles for the Cutaneous Delivery of Cannabidiol International Journal of Molecular Sciences 23 (6165). ISSN: 14220067. doi: 10.3390/ijms23116165.

Major anthocyanins in elderberry effectively trap methylglyoxal and reduce cytotoxicity of methylglyoxal in HepG2 cell line
Ferreira S.S., Domingues M.R., Barros C., Santos S.A.O., Silvestre A.J.D., Silva A.M., Nunes F.M., (2022) Major anthocyanins in elderberry effectively trap methylglyoxal and reduce cytotoxicity of methylglyoxal in HepG2 cell line Food Chemistry: X 16 (100468). ISSN: 25901575. doi: 10.1016/j.fochx.2022.100468.

Microemulsions and Nanoemulsions in Skin Drug Delivery
Souto E.B., Cano A., Martins-Gomes C., Coutinho T.E., Zielińska A., Silva A.M., (2022) Microemulsions and Nanoemulsions in Skin Drug Delivery Bioengineering 9 (158). ISSN: 23065354. doi: 10.3390/bioengineering9040158.

Molecular Characterization of Thymus capitellatus Extracts and Their Antioxidant, Neuroprotective and Anti-Proliferative Activities
Martins-Gomes C., Steck J., Keller J., Bunzel M., Nunes F.M., Silva A.M., (2022) Molecular Characterization of Thymus capitellatus Extracts and Their Antioxidant, Neuroprotective and Anti-Proliferative Activities International Journal of Molecular Sciences 23 (15187). ISSN: 14220067. doi: 10.3390/ijms232315187.

Molecular Physicochemical Properties of Selected Pesticides as Predictive Factors for Oxidative Stress and Apoptosis-Dependent Cell Death in Caco-2 and HepG2 Cells
Silva A.M., Martins-Gomes C., Ferreira S.S., Souto E.B., Andreani T., (2022) Molecular Physicochemical Properties of Selected Pesticides as Predictive Factors for Oxidative Stress and Apoptosis-Dependent Cell Death in Caco-2 and HepG2 Cells International Journal of Molecular Sciences 23 (8107). ISSN: 14220067. doi: 10.3390/ijms23158107.

Nanophytosomes: a novel approach for the delivery of herbal drugs
Martins-Gomes C., Souto E.B., Silva A.M., (2022) Nanophytosomes: a novel approach for the delivery of herbal drugs Systems of Nanovesicular Drug Delivery :239-257. doi: 10.1016/B978-0-323-91864-0.00015-2.

Nanotechnologies to deliver drugs through the blood–brain and blood–retinal barriers
Costa M.C., Shegokar R., Silva A.M., Souto E.B., (2022) Nanotechnologies to deliver drugs through the blood–brain and blood–retinal barriers Nanotechnology and Regenerative Medicine: History, Techniques, Frontiers, and Applications :45-64. doi: 10.1016/B978-0-323-90471-1.00010-4.

Neurotoxicity Assessment of Four Different Pesticides Using In Vitro Enzymatic Inhibition Assays
Martins-Gomes C., Coutinho T.E., Silva T.L., Andreani T., Silva A.M., (2022) Neurotoxicity Assessment of Four Different Pesticides Using In Vitro Enzymatic Inhibition Assays Toxics 10 (448). ISSN: 23056304. doi: 10.3390/toxics10080448.

Permeability, anti-inflammatory and anti-VEGF profiles of steroidal-loaded cationic nanoemulsions in retinal pigment epithelial cells under oxidative stress
Fernandes A.R., dos Santos T., Granja P.L., Sanchez-Lopez E., Garcia M.L., Silva A.M., Souto E.B., (2022) Permeability, anti-inflammatory and anti-VEGF profiles of steroidal-loaded cationic nanoemulsions in retinal pigment epithelial cells under oxidative stress International Journal of Pharmaceutics 617 (121615). ISSN: 18733476. doi: 10.1016/j.ijpharm.2022.121615.

Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery
Souto E.B., Fangueiro J.F., Fernandes A.R., Cano A., Sanchez-Lopez E., Garcia M.L., Severino P., Paganelli M.O., Chaud M.V., Silva A.M., (2022) Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery Heliyon 8 (e08938). doi: 10.1016/j.heliyon.2022.e08938.

Production Technologies, Regulatory Parameters, and Quality Control of Vaccine Vectors for Veterinary Use
Barbosa R.d.M., Silva A.M., Silva C.F.d., Cardoso J.C., Severino P., Meirelles L.M.A., Silva-Junior A.A.d., Viseras C., Fonseca J., Souto E.B., (2022) Production Technologies, Regulatory Parameters, and Quality Control of Vaccine Vectors for Veterinary Use Technologies 10 (109). ISSN: 22277080. doi: 10.3390/technologies10050109.

Progress of nanotechnology in the development of medicines
Formoso I., Shegokar R., Zielinska A., Eder P., Silva A.M., Souto E.B., (2022) Progress of nanotechnology in the development of medicines Nanotechnology and Regenerative Medicine: History, Techniques, Frontiers, and Applications :1-21. doi: 10.1016/B978-0-323-90471-1.00001-3.

Prunus lusitanica L. Fruits as a Novel Source of Bioactive Compounds with Antioxidant Potential: Exploring the Unknown
Abraão A.S., Fernandes N., Silva A.M., Domínguez-Perles R., Barros A., (2022) Prunus lusitanica L. Fruits as a Novel Source of Bioactive Compounds with Antioxidant Potential: Exploring the Unknown Antioxidants 11 (1738). ISSN: 20763921. doi: 10.3390/antiox11091738.

Selected Flavonoids to Target Melanoma: A Perspective in Nanoengineering Delivery Systems
Coutinho T.E., Souto E.B., Silva A.M., (2022) Selected Flavonoids to Target Melanoma: A Perspective in Nanoengineering Delivery Systems Bioengineering 9 (290). ISSN: 23065354. doi: 10.3390/bioengineering9070290.

Toxicological screening of nanoparticles for biological applications: Drosophila melanogaster as a representative toxicological model
Severino P., Dias-Ferreira J., Andrade L.N., Lima D.M., de Hollanda L.M., da Silva C.F., Chaud M.V., Carbone C., Silva A.M., Lucarini M., Durazzo A., Capasso R., Santini A., Souto E.B., (2022) Toxicological screening of nanoparticles for biological applications: Drosophila melanogaster as a representative toxicological model Nanotechnology and Regenerative Medicine: History, Techniques, Frontiers, and Applications :551-573. doi: 10.1016/B978-0-323-90471-1.00007-4.

Uncaria tomentosa (Willd. ex Schult.): Focus on Nutraceutical Aspects
Nazhand A., Durazzo A., Lucarini M., Silva A.M., Souto S.B., Severino P., Souto E.B., Santini A., (2022) Uncaria tomentosa (Willd. ex Schult.): Focus on Nutraceutical Aspects Current Bioactive Compounds 18 (e021221196131). ISSN: 18756646. doi: 10.2174/1573407217666210903113347.

Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role
Durazzo A., Nazhand A., Lucarini M., Silva A.M., Souto S.B., Guerra F., Severino P., Zaccardelli M., Souto E.B., Santini A., (2021) Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role Rendiconti Lincei 32 :625-642. ISSN: 17200776. doi: 10.1007/s12210-021-01003-2.

Biosurfactants: Properties and applications in drug delivery, biotechnology and ecotoxicology
Bjerk T.R., Severino P., Jain S., Marques C., Silva A.M., Pashirova T., Souto E.B., (2021) Biosurfactants: Properties and applications in drug delivery, biotechnology and ecotoxicology Bioengineering 8 (115). ISSN: 23065354. doi: 10.3390/bioengineering8080115.

Dabco-customized nanoemulsions: Characterization, cell viability and genotoxicity in retinal pigmented epithelium and microglia cells
Fernandes A.R., Dos Santos T., Granja P.L., Sanchez-Lopez E., Santini A., Garcia M.L., Silva A.M., Souto E.B., (2021) Dabco-customized nanoemulsions: Characterization, cell viability and genotoxicity in retinal pigmented epithelium and microglia cells Pharmaceutics 13 (1652). ISSN: 19994923. doi: 10.3390/pharmaceutics13101652.

Development and characterization of nanoemulsions for ophthalmic applications: Role of cationic surfactants
Fernandes A.R., Sanchez-Lopez E., Dos Santos T., Garcia M.L., Silva A.M., Souto E.B., (2021) Development and characterization of nanoemulsions for ophthalmic applications: Role of cationic surfactants Materials 14 (7541). ISSN: 19961944. doi: 10.3390/ma14247541.

Ecotoxicity to freshwater organisms and cytotoxicity of nanomaterials: Are we generating sufficient data for their risk assessment?
Andreani T., Nogueira V., Gavina A., Fernandes S., Rodrigues J.L., Pinto V.V., Ferreira M.J., Silva A.M., Pereira C.M., Pereira R., (2021) Ecotoxicity to freshwater organisms and cytotoxicity of nanomaterials: Are we generating sufficient data for their risk assessment? Nanomaterials 11 (66) :1-25. ISSN: 20794991. doi: 10.3390/nano11010066.

Genotoxicity assessment of metal-based nanocomposites applied in drug delivery
Cardoso S., da Silva C.F., Severino P., Silva A.M., Souto S.B., Zielińska A., Karczewski J., Souto E.B., (2021) Genotoxicity assessment of metal-based nanocomposites applied in drug delivery Materials 14 (6551). ISSN: 19961944. doi: 10.3390/ma14216551.

Mono-and dicationic dabco/quinuclidine composed nanomaterials for the loading of steroidal drug: 32 factorial design and physicochemical characterization
Fernandes A.R., Sanchez-Lopez E., Santini A., Dos Santos T., Garcia M.L., Silva A.M., Souto E.B., (2021) Mono-and dicationic dabco/quinuclidine composed nanomaterials for the loading of steroidal drug: 32 factorial design and physicochemical characterization Nanomaterials 11 (2758). ISSN: 20794991. doi: 10.3390/nano11102758.

Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
Silva A.M., Félix L.M., Teixeira I., Martins-Gomes C., Schäfer J., Souto E.B., Santos D.J., Bunzel M., Nunes F.M., (2021) Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits Food Chemistry: X 12 (100171). ISSN: 25901575. doi: 10.1016/j.fochx.2021.100171.

Red seaweeds strengthening the nexus between nutrition and health: phytochemical characterization and bioactive properties of Grateloupia turuturu and Porphyra umbilicalis extracts
Ferreira J., Hartmann A., Martins-Gomes C., Nunes F.M., Souto E.B., Santos D.L., Abreu H., Pereira R., Pacheco M., Gaivão I., Silva A.M., (2021) Red seaweeds strengthening the nexus between nutrition and health: phytochemical characterization and bioactive properties of Grateloupia turuturu and Porphyra umbilicalis extracts Journal of Applied Phycology 33 :3365-3381. ISSN: 15735176. doi: 10.1007/s10811-021-02529-6.

(+)-limonene 1,2-epoxide-loaded slns: Evaluation of drug release, antioxidant activity, and cytotoxicity in an HaCaT cell line
Souto E.B., Zielinska A., Souto S.B., Durazzo A., Lucarini M., Santini A., Silva A.M., Atanasov A.G., Marques C., Andrade L.N., Severino P., (2020) (+)-limonene 1,2-epoxide-loaded slns: Evaluation of drug release, antioxidant activity, and cytotoxicity in an HaCaT cell line International Journal of Molecular Sciences 21 (1449). ISSN: 14220067. doi: 10.3390/ijms21041449.

Chemical characterization and bioactivity of extracts from Thymus mastichina: A thymus with a distinct salvianolic acid composition
Taghouti M., Martins-Gomes C., Schäfer J., Santos J.A., Bunzel M., Nunes F.M., Silva A.M., (2020) Chemical characterization and bioactivity of extracts from Thymus mastichina: A thymus with a distinct salvianolic acid composition Antioxidants 9 (34). ISSN: 20763921. doi: 10.3390/antiox9010034.

Diabetic retinopathy and ocular melanoma: How far we are?
Souto E.B., Campos J.R., Da Ana R., Fangueiro J.F., Martins-Gomes C., Durazzo A., Lucarini M., López E.S., Espina M., García M.L., Silva A.M., Mendonça F., Santini A., Souto S.B., (2020) Diabetic retinopathy and ocular melanoma: How far we are? Applied Sciences (Switzerland) 10 (2777). ISSN: 20763417. doi: 10.3390/APP10082777.

Effect of harvesting year and elderberry cultivar on the chemical composition and potential bioactivity: A three-year study
Ferreira S.S., Silva P., Silva A.M., Nunes F.M., (2020) Effect of harvesting year and elderberry cultivar on the chemical composition and potential bioactivity: A three-year study Food Chemistry 302 (125366). ISSN: 18737072. doi: 10.1016/j.foodchem.2019.125366.

Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection
Andreani T., Dias-Ferreira J., Fangueiro J.F., Souza A.L.R., Kiill C.P., Gremião M.P.D., García M.L., Silva A.M., Souto E.B., (2020) Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection Heliyon 6 (e03831). doi: 10.1016/j.heliyon.2020.e03831.

Hawthorn (Crataegus spp.): An updated overview on its beneficial properties
Nazhand A., Lucarini M., Durazzo A., Zaccardelli M., Cristarella S., Souto S.B., Silva A.M., Severino P., Souto E.B., Santini A., (2020) Hawthorn (Crataegus spp.): An updated overview on its beneficial properties Forests 11 (564). ISSN: 19994907. doi: 10.3390/F11050564.

In vitro characterization, modelling, and antioxidant properties of polyphenon-60 from green tea in eudragit s100-2 chitosan microspheres
Souto E.B., da Ana R., Souto S.B., Zielińska A., Marques C., Andrade L.N., Horbańczuk O.K., Atanasov A.G., Lucarini M., Durazzo A., Silva A.M., Novellino E., Santini A., Severino P., (2020) In vitro characterization, modelling, and antioxidant properties of polyphenon-60 from green tea in eudragit s100-2 chitosan microspheres Nutrients 12 (967). ISSN: 20726643. doi: 10.3390/nu12040967.

In vitro phototherapeutic effects of indolenine-based mono- and dithiosquaraine cyanine dyes against Caco-2 and HepG2 human cancer cell lines
Fernandes T.C.D., Lima E., Boto R.E., Ferreira D., Fernandes J.R., Almeida P., Ferreira L.F.V., Silva A.M., Reis L.V., (2020) In vitro phototherapeutic effects of indolenine-based mono- and dithiosquaraine cyanine dyes against Caco-2 and HepG2 human cancer cell lines Photodiagnosis and Photodynamic Therapy 31 (101844). ISSN: 18731597. doi: 10.1016/j.pdpdt.2020.101844.

Lipid nanoparticles as carriers for the treatment of neurodegeneration associated with alzheimer’s disease and glaucoma: Present and future challenges
Lopez E.S., Machado A.L.L., Vidal L.B., Gonzalez-Pizarro R., Silva A.D., Souto E.B., (2020) Lipid nanoparticles as carriers for the treatment of neurodegeneration associated with alzheimer’s disease and glaucoma: Present and future challenges Current Pharmaceutical Design 26 :1235-1250. ISSN: 18734286. doi: 10.2174/1381612826666200218101231.

Metal-based nanoparticles as antimicrobial agents: An overview
Sánchez-López E., Gomes D., Esteruelas G., Bonilla L., Lopez-Machado A.L., Galindo R., Cano A., Espina M., Ettcheto M., Camins A., Silva A.M., Durazzo A., Santini A., Garcia M.L., Souto E.B., (2020) Metal-based nanoparticles as antimicrobial agents: An overview Nanomaterials 10 (292). ISSN: 20794991. doi: 10.3390/nano10020292.

Multiple cell signalling pathways of human proinsulin C-peptide in vasculopathy protection
Souto S.B., Campos J.R., Fangueiro J.F., Silva A.M., Cicero N., Santini A., Souto E.B., (2020) Multiple cell signalling pathways of human proinsulin C-peptide in vasculopathy protection International Journal of Molecular Sciences 21 (645). ISSN: 14220067. doi: 10.3390/ijms21020645.

Nanomaterials for skin delivery of cosmeceuticals and pharmaceuticals
Souto E.B., Fernandes A.R., Martins-Gomes C., Coutinho T.E., Durazzo A., Lucarini M., Souto S.B., Silva A.M., Santini A., (2020) Nanomaterials for skin delivery of cosmeceuticals and pharmaceuticals Applied Sciences (Switzerland) 10 (1594). ISSN: 20763417. doi: 10.3390/app10051594.

Ocular cell lines and genotoxicity assessment
Souto E.B., Campos J.R., Da Ana R., Martins-Gomes C., Silva A.M., Souto S.B., Lucarini M., Durazzo A., Santini A., (2020) Ocular cell lines and genotoxicity assessment International Journal of Environmental Research and Public Health 17 (2046). ISSN: 16604601. doi: 10.3390/ijerph17062046.

Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice
de Jesus D.F., Orime K., Kaminska D., Kimura T., Basile G., Wang C.H., Haertle L., Riemens R., Brown N.K., Hu J., Männistö V., Silva A.M., Dirice E., Tseng Y.H., Haaf T., Pihlajamäki J., Kulkarni R.N., (2020) Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice Journal of Clinical Investigation 130 :2391-2404. ISSN: 15588238. doi: 10.1172/JCI127502.

Perillaldehyde 1,2-epoxide loaded SLN-tailored mAb: Production, physicochemical characterization and in vitro cytotoxicity profile in MCF-7 cell lines
Souto E.B., Souto S.B., Zielinska A., Durazzo A., Lucarini M., Santini A., Horbańczuk O.K., Atanasov A.G., Marques C., Andrade L.N., Silva A.M., Severino P., (2020) Perillaldehyde 1,2-epoxide loaded SLN-tailored mAb: Production, physicochemical characterization and in vitro cytotoxicity profile in MCF-7 cell lines Pharmaceutics 12 (161). ISSN: 19994923. doi: 10.3390/pharmaceutics12020161.

Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology
Zielinska A., Carreiró F., Oliveira A.M., Neves A., Pires B., Nagasamy Venkatesh D., Durazzo A., Lucarini M., Eder P., Silva A.M., Santini A., Souto E.B., (2020) Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology Molecules 25 (3731). ISSN: 14203049. doi: 10.3390/molecules25163731.

Polyphenol composition and biological activity of Thymus citriodorus and Thymus vulgaris: Comparison with endemic Iberian Thymus species
Taghouti M., Martins-Gomes C., Félix L.M., Schäfer J., Santos J.A., Bunzel M., Nunes F.M., Silva A.M., (2020) Polyphenol composition and biological activity of Thymus citriodorus and Thymus vulgaris: Comparison with endemic Iberian Thymus species Food Chemistry 331 (127362). ISSN: 18737072. doi: 10.1016/j.foodchem.2020.127362.

Potential application of grape (Vitis vinifera L.) stem extracts in the cosmetic and pharmaceutical industries: Valorization of a by-product
Leal C., Gouvinhas I., Santos R.A., Rosa E., Silva A.M., Saavedra M.J., Barros A.I.R.N.A., (2020) Potential application of grape (Vitis vinifera L.) stem extracts in the cosmetic and pharmaceutical industries: Valorization of a by-product Industrial Crops and Products 154 (112675). doi: 10.1016/j.indcrop.2020.112675.

Quinoline-and benzoselenazole-derived unsymmetrical squaraine cyanine dyes: Design, synthesis, photophysicochemical features and light-triggerable antiproliferative effects against breast cancer cell lines
Lima E., Boto R.E., Ferreira D., Fernandes J.R., Almeida P., Ferreira L.F.V., Souto E.B., Silva A.M., Reis L.V., (2020) Quinoline-and benzoselenazole-derived unsymmetrical squaraine cyanine dyes: Design, synthesis, photophysicochemical features and light-triggerable antiproliferative effects against breast cancer cell lines Materials 13 (2646). ISSN: 19961944. doi: 10.3390/ma13112646.

Red and near-infrared absorbing dicyanomethylene squaraine cyanine dyes: Photophysicochemical properties and anti-tumor photosensitizing effects
Martins T.D., Lima E., Boto R.E., Ferreira D., Fernandes J.R., Almeida P., Ferreira L.F.V., Silva A.M., Reis L.V., (2020) Red and near-infrared absorbing dicyanomethylene squaraine cyanine dyes: Photophysicochemical properties and anti-tumor photosensitizing effects Materials 13 (2083). ISSN: 19961944. doi: 10.3390/ma13092083.

Sage species case study on a spontaneous mediterranean plant to control phytopathogenic fungi and bacteria
Zaccardelli M., Pane C., Caputo M., Durazzo A., Lucarini M., Silva A.M., Severino P., Souto E.B., Santini A., De Feo V., (2020) Sage species case study on a spontaneous mediterranean plant to control phytopathogenic fungi and bacteria Forests 11 (704) :1-20. ISSN: 19994907. doi: 10.3390/f11060704.

Sucupira oil-loaded nanostructured lipid carriers (NLC): Lipid screening, factorial design, release profile, and cytotoxicity
Vieira R., Severino P., Nalone L.A., Souto S.B., Silva A.M., Lucarini M., Durazzo A., Santini A., Souto E.B., (2020) Sucupira oil-loaded nanostructured lipid carriers (NLC): Lipid screening, factorial design, release profile, and cytotoxicity Molecules 25 (685). ISSN: 14203049. doi: 10.3390/molecules25030685.

The nutraceutical value of carnitine and its use in dietary supplements
Durazzo A., Lucarini M., Nazhand A., Souto S.B., Silva A.M., Severino P., Souto E.B., Santini A., (2020) The nutraceutical value of carnitine and its use in dietary supplements Molecules 25 (molecules25092127). ISSN: 14203049. doi: 10.3390/molecules25092127.

Thymus zygis subsp. zygis an endemic portuguese plant: Phytochemical profiling, antioxidant, anti-proliferative and anti-inflammatory activities
Silva A.M., Martins-Gomes C., Souto E.B., Schäfer J., Santos J.A., Bunzel M., Nunes F.M., (2020) Thymus zygis subsp. zygis an endemic portuguese plant: Phytochemical profiling, antioxidant, anti-proliferative and anti-inflammatory activities Antioxidants 9 (482). ISSN: 20763921. doi: 10.3390/antiox9060482.

Two-and three-dimensional spectrofluorimetric qualitative analysis of selected vegetable oils for biomedical applications
Zielińska A., Kubasiewicz K., Wójcicki K., Silva A.M., Nunes F.M., Szalata M., Słomski R., Eder P., Souto E.B., (2020) Two-and three-dimensional spectrofluorimetric qualitative analysis of selected vegetable oils for biomedical applications Molecules 25 (5608). ISSN: 14203049. doi: 10.3390/molecules25235608.

Vitex agnus-castus l.: Main features and nutraceutical perspectives
Souto E.B., Durazzo A., Nazhand A., Lucarini M., Zaccardelli M., Souto S.B., Silva A.M., Severino P., Novellino E., Santini A., (2020) Vitex agnus-castus l.: Main features and nutraceutical perspectives Forests 11 (761). ISSN: 19994907. doi: 10.3390/f11070761.

3D printing in the design of pharmaceutical dosage forms
Souto E.B., Campos J.C., Filho S.C., Teixeira M.C., Martins-Gomes C., Zielinska A., Carbone C., Silva A.M., (2019) 3D printing in the design of pharmaceutical dosage forms Pharmaceutical Development and Technology 24 :1044-1053. ISSN: 10979867. doi: 10.1080/10837450.2019.1630426.

Cationic surfactants: Self-assembly, structure-activity correlation and their biological applications
Zakharova L.Y., Pashirova T.N., Doktorovova S., Fernandes A.R., Sanchez-Lopez E., Silva A.M., Souto S.B., Souto E.B., (2019) Cationic surfactants: Self-assembly, structure-activity correlation and their biological applications International Journal of Molecular Sciences 20 (5534). ISSN: 14220067. doi: 10.3390/ijms20225534.

Clotrimazole-loaded mediterranean essential oils NLC: A synergic treatment of Candida skin infections
Carbone C., Teixeira M.D.C., Sousa M.D.C., Martins-Gomes C., Silva A.M., Souto E.M.B., Musumeci T., (2019) Clotrimazole-loaded mediterranean essential oils NLC: A synergic treatment of Candida skin infections Pharmaceutics 11 (231). ISSN: 19994923. doi: 10.3390/pharmaceutics11050231.

Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines
Silva A.M., Martins-Gomes C., Fangueiro J.F., Andreani T., Souto E.B., (2019) Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines Pharmaceutical Development and Technology 24 :1243-1249. ISSN: 10979867. doi: 10.1080/10837450.2019.1658774.

Development and optimization of alpha-pinene-loaded solid lipid nanoparticles (SLN) using experimental factorial design and dispersion analysis
Zielinska A., Ferreira N.R., Durazzo A., Lucarini M., Cicero N., El Mamouni S., Silva A.M., Nowak I., Santini A., Souto E.B., (2019) Development and optimization of alpha-pinene-loaded solid lipid nanoparticles (SLN) using experimental factorial design and dispersion analysis Molecules 24 (2683). ISSN: 14203049. doi: 10.3390/molecules24152683.

Ginkgo biloba L. Leaf extract protects HepG2 cells against paraquat-induced oxidative DNA damage
Silva A.M., Silva S.C., Soares J.P., Martins-Gomes C., Teixeira J.P., Leal F., Gaivão I., (2019) Ginkgo biloba L. Leaf extract protects HepG2 cells against paraquat-induced oxidative DNA damage Plants 8 (556). ISSN: 22237747. doi: 10.3390/plants8120556.

In vitro cytotoxicity of oleanolic/ursolic acids-loaded in PLGA nanoparticles in different cell lines
Silva A.M., Alvarado H.L., Abrego G., Martins-Gomes C., Garduño-Ramirez M.L., García M.L., Calpena A.C., Souto E.B., (2019) In vitro cytotoxicity of oleanolic/ursolic acids-loaded in PLGA nanoparticles in different cell lines Pharmaceutics 11 (362). ISSN: 19994923. doi: 10.3390/pharmaceutics11080362.

Key production parameters for the development of solid lipid nanoparticles by high shear homogenization
Souto E., Doktorovova S., Zielinska A., Silva A., (2019) Key production parameters for the development of solid lipid nanoparticles by high shear homogenization Pharmaceutical Development and Technology 24 :1181-1185. ISSN: 10979867. doi: 10.1080/10837450.2019.1647235.

Meglumine-based supra-amphiphile self-assembled in water as a skin drug delivery system: Influence of unfrozen bound water in the system bioadhesiveness
de Souza A.L.R., Fonseca M., Ferreira L.M.B., Kurokawa S.S.S., Kiill C.P., Ferreira N.N., dos Santos Pyrrho A., Sarmento V.H.V., Silva A.M., Gremião M.P.D., Ribeiro C.A., (2019) Meglumine-based supra-amphiphile self-assembled in water as a skin drug delivery system: Influence of unfrozen bound water in the system bioadhesiveness Colloids and Surfaces B: Biointerfaces 184 (110523). ISSN: 18734367. doi: 10.1016/j.colsurfb.2019.110523.

Microemulsions: Principles, Scope, Methods, and Applications in Transdermal Drug Delivery.
Pereira, Irina; Antunes, Sara; Santos,Ana C.; Veiga, Francisco J.; Silva, Amélia M.; Boonme, Prapaporn; Souto, Eliana B. (2019) Microemulsions: Principles, Scope, Methods, and Applications in Transdermal Drug Delivery. In: Deepak Kumar Verma, Megh R. Goyal, Hafiz Anasr Rasul Suleria (Eds). Nanotechnology and Nanomaterial Applications in Food, Health and Biomedical Sciences”, PART I: NANOTECHNOLOGY TECHNIQUE (Chapter 2) :91-118. ISBN: 9781771887649.

Myasthenia gravis: State of the art and new therapeutic strategies
Souto E.B., Lima B., Campos J.R., Martins-Gomes C., Souto S.B., Silva A.M., (2019) Myasthenia gravis: State of the art and new therapeutic strategies Journal of Neuroimmunology 337 (577080). ISSN: 18728421. doi: 10.1016/j.jneuroim.2019.577080.

Nanoparticle delivery systems in the treatment of diabetes complications
Souto E.B., Souto S.B., Campos J.R., Severino P., Pashirova T.N., Zakharova L.Y., Silva A.M., Durazzo A., Lucarini M., Izzo A.A., Santini A., (2019) Nanoparticle delivery systems in the treatment of diabetes complications Molecules 24 (4209). ISSN: 14203049. doi: 10.3390/molecules24234209.

Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human Colon adenocarcinoma cell line
Campos J.R., Fernandes A.R., Sousa R., Fangueiro J.F., Boonme P., Garcia M.L., Silva A.M., Naveros B.C., Souto E.B., (2019) Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human Colon adenocarcinoma cell line Pharmaceutical Development and Technology 24 :616-622. ISSN: 10979867. doi: 10.1080/10837450.2018.1549075.

Photophysicochemical properties and in vitro phototherapeutic effects of iodoquinoline- and benzothiazole-derived unsymmetrical squaraine cyanine dyes
Friães S., Lima E., Boto R.E., Ferreira D., Fernandes J.R., Ferreira L.F.V., Silva A.M., Reis L.V., (2019) Photophysicochemical properties and in vitro phototherapeutic effects of iodoquinoline- and benzothiazole-derived unsymmetrical squaraine cyanine dyes Applied Sciences (Switzerland) 9 (5414). ISSN: 20763417. doi: 10.3390/app9245414.

Polyphenols for skin cancer: Chemical properties, structure-related mechanisms of action and new delivery systems
Souto E., Sampaio A., Campos J., Martins-Gomes C., Aires A., Silva A., (2019) Polyphenols for skin cancer: Chemical properties, structure-related mechanisms of action and new delivery systems Studies in Natural Products Chemistry 63 :21-42. ISBN: 9780128179017. doi: 10.1016/B978-0-12-817901-7.00002-2.

Rosmarinic Acid: Sources, Bioactivities and Health Benefits.
Martins-Gomes, Carlos; Nunes, Fernando M.; Sampaio, Ana C.; Souto, Eliana B.; Silva, Amélia M. (2019) Rosmarinic Acid: Sources, Bioactivities and Health Benefits. IN: Ryan, Iman (Ed.) Phytochemicals: Plant Sources and Potential Health Benefits. Book Series: Plant Science Research and Practices. NovaScience Publishers, New York, USA (Chapter 4) :109-146. ISBN: 978-1-53615-478-8.

Soft cationic nanoparticles for drug delivery: Production and cytotoxicity of solid lipid nanoparticles (SLNs)
Silva A.M., Martins-Gomes C., Coutinho T.E., Fangueiro J.F., Sanchez-Lopez E., Pashirova T.N., Andreani T., Souto E.B., (2019) Soft cationic nanoparticles for drug delivery: Production and cytotoxicity of solid lipid nanoparticles (SLNs) Applied Sciences (Switzerland) 9 (4438). ISSN: 20763417. doi: 10.3390/app9204438.

Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome—review of classical and new compounds: Part-i
Vieira R., Souto S.B., Sánchez-López E., Machado A.L., Severino P., Jose S., Santini A., Fortuna A., García M.L., Silva A.M., Souto E.B., (2019) Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome—review of classical and new compounds: Part-i Pharmaceuticals 12 (152). ISSN: 14248247. doi: 10.3390/ph12040152.

Surface-tailored anti-HER2/neu-solid lipid nanoparticles for site-specific targeting MCF-7 and BT-474 breast cancer cells
Souto E.B., Doktorovova S., Campos J.R., Martins-Lopes P., Silva A.M., (2019) Surface-tailored anti-HER2/neu-solid lipid nanoparticles for site-specific targeting MCF-7 and BT-474 breast cancer cells European Journal of Pharmaceutical Sciences 128 :27-35. ISSN: 18790720. doi: 10.1016/j.ejps.2018.11.022.

The influence of polysaccharide coating on the physicochemical parameters and cytotoxicity of silica nanoparticles for hydrophilic biomolecules delivery
Andreani T., Fangueiro J., Severino P., de Souza A., Martins-Gomes C., Fernandes P., Calpena A., Gremião M., Souto E., Silva A., (2019) The influence of polysaccharide coating on the physicochemical parameters and cytotoxicity of silica nanoparticles for hydrophilic biomolecules delivery Nanomaterials 9 (1081). ISSN: 20794991. doi: 10.3390/nano9081081.

Therapeutic interventions for countering leishmaniasis and chagas’s disease: From traditional sources to nanotechnological systems
Souto E.B., Dias-Ferreira J., Craveiro S.A., Severino P., Sanchez-Lopez E., Garcia M.L., Silva A.M., Souto S.B., Mahant S., (2019) Therapeutic interventions for countering leishmaniasis and chagas’s disease: From traditional sources to nanotechnological systems Pathogens 8 (119). ISSN: 20760817. doi: 10.3390/pathogens8030119.

Thymus carnosus extracts induce anti-proliferative activity in Caco-2 cells through mechanisms that involve cell cycle arrest and apoptosis
Martins-Gomes C., Souto E.B., Cosme F., Nunes F.M., Silva A.M., (2019) Thymus carnosus extracts induce anti-proliferative activity in Caco-2 cells through mechanisms that involve cell cycle arrest and apoptosis Journal of Functional Foods 54 :128-135. doi: 10.1016/j.jff.2019.01.010.

Trends in atopic dermatitis—from standard pharmacotherapy to novel drug delivery systems
Souto E.B., Dias-Ferreira J., Oliveira J., Sanchez-Lopez E., Lopez-Machado A., Espina M., Garcia M.L., Souto S.B., Martins-Gomes C., Silva A.M., (2019) Trends in atopic dermatitis—from standard pharmacotherapy to novel drug delivery systems International Journal of Molecular Sciences 20 (5659). ISSN: 14220067. doi: 10.3390/ijms20225659.

Uveal melanoma: physiopathology and new in situ-specific therapies
Souto E.B., Zielinska A., Luis M., Carbone C., Martins-Gomes C., Souto S.B., Silva A.M., (2019) Uveal melanoma: physiopathology and new in situ-specific therapies Cancer Chemotherapy and Pharmacology 84 :15-32. ISSN: 14320843. doi: 10.1007/s00280-019-03860-z.

Anti-inflammatory and Anti-cancer Activity of Citral: Optimization of Citral-loaded Solid Lipid Nanoparticles (SLN) using Experimental Factorial Design and LUMiSizer.
Zielińska, Alexandra; Martins-Gomes, Carlos; Ferreira, Nuno R. ; Silva, Amélia M.; Nowak, I.; Souto, Eliana B. (2018) Anti-inflammatory and Anti-cancer Activity of Citral: Optimization of Citral-loaded Solid Lipid Nanoparticles (SLN) using Experimental Factorial Design and LUMiSizer. INTERNATIONAL JOURNAL OF PHARMACEUTICS 553 (2-Jan) :428-440. doi: 10.1016/j.ijpharm.2018.10.065. (Impact factor, Quartile: 3.862, Q1).

Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss.
Martins-Gomes, Carlos; Taghouti, Meriem; Schaefer, Judith; Bunzel, Mirko; Silva, Amelia M.; Nunes, Fernando M. (2018) Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss. Journal Of Functional Foods 43 :154-164. doi: 10.1016/j.jff.2018.02.012. (Impact factor, Quartile: 3.47, Q1).

Citrus reticulata Blanco peels as a source of antioxidant and anti-proliferative phenolic compounds.
Ferreira, Sandrine S.; Silva, Amelia M.; Nunes, Fernando M. (2018) Citrus reticulata Blanco peels as a source of antioxidant and anti-proliferative phenolic compounds. Industrial Crops And Products 111 :141-148. doi: 10.1016/j.indcrop.2017.10.009. (Impact factor, Quartile: 3.849, Q1).

Hansen solubility parameters (HSP) for prescreening formulation of solid lipid nanoparticles (SLN): in vitro testing of curcumin-loaded SLN in MCF-7 and BT-474 cell lines.
Doktorovova, Slavomira; Souto, Eliana B.; Silva, Amelia M. (2018) Hansen solubility parameters (HSP) for prescreening formulation of solid lipid nanoparticles (SLN): in vitro testing of curcumin-loaded SLN in MCF-7 and BT-474 cell lines. Pharmaceutical Development And Technology 23 (1) :96-105. doi: 10.1080/10837450.2017.1384491. (Impact factor, Quartile: 1.945, Q3).

Linalool Bioactive Properties and Potential Applicability in Drug Delivery Systems.
Pereira, I.; Severino, Patrícia; Santos, Ana C.; Silva, Amélia M.; Souto, Eliana B. (2018) Linalool Bioactive Properties and Potential Applicability in Drug Delivery Systems. Colloids And Surfaces B-Biointerfaces 171 :566-578. doi: 10.1016/j.colsurfb.2018.08.001. (Impact factor, Quartile: 3.997, Q1).

Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles.
Carbone, C.; Martins-Gomes, C.; Caddeo, C.; Silva, A. M.; Musumeci, T.; Pignatello, R.; Puglisi, G.; Souto, E. B. (2018) Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles. International Journal Of Pharmaceutics 548 (1) :217-226. doi: 10.1016/j.ijpharm.2018.06.064. (Impact factor, Quartile: 3.862, Q1).

Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization.
Sanchez-Lopez, Elena; Ettcheto, Miren; Antonia Egea, Maria; Espina, Marta; Cano, Amanda; Cristina Calpena, Ana; Camins, Antoni; Carmona, Nuria; Silva, Amelia M.; Souto, Eliana B.; Luisa Garcia, Maria (2018) Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization. Journal Of Nanobiotechnology 16. doi: 10.1186/s12951-018-0356-z. (Impact factor, Quartile: 5.294, Q1).

Memantine-Loaded PEGylated Biodegradable Nanoparticles for the Treatment of Glaucoma.
Sanchez-Lopez, Elena; Antonia Egea, Maria; Davis, Benjamin Michael; Guo, Li; Espina, Marta; Silva, Amelia Maria; Cristina Calpena, Ana; Barbosa Souto, Eliana Maria; Ravindran, Nivedita; Ettcheto, Miren; Camins, Antonio; Luisa Garcia, Maria; Cordeiro, Maria Francesca (2018) Memantine-Loaded PEGylated Biodegradable Nanoparticles for the Treatment of Glaucoma. Small 14 (2). doi: 10.1002/smll.201701808. (Impact factor, Quartile: 9.598, Q1).

Optimization of Linalool-loaded Solid Lipid Nanoparticles using Experimental Factorial Design and Long-term Stability Studies with a New Centrifugal Sedimentation Method.
Pereira, I.; Alexandra Zielińska; Nuno R. Ferreira; Amélia M. Silva; Eliana B. Souto (2018) Optimization of Linalool-loaded Solid Lipid Nanoparticles using Experimental Factorial Design and Long-term Stability Studies with a New Centrifugal Sedimentation Method. International Journal Of Pharmaceutics 549 (1) :261-270. doi: 10.1016/j.ijpharm.2018.07.068. (Impact factor, Quartile: 3.862, Q1).

Optimization, Biopharmaceutical Profile and Therapeutic Efficacy of Pioglitazone-loaded PLGA-PEG Nanospheres as a Novel Strategy for Ocular Inflammatory Disorders.
Silva-Abreu, Marcelle; Cristina Calpena, Ana; Espina, Marta; Silva, Amelia M.; Gimeno, Alvaro; Antonia Egea, Maria; Luisa Garcia, Maria (2018) Optimization, Biopharmaceutical Profile and Therapeutic Efficacy of Pioglitazone-loaded PLGA-PEG Nanospheres as a Novel Strategy for Ocular Inflammatory Disorders. Pharmaceutical Research 35 (1). doi: 10.1007/s11095-017-2319-8. (Impact factor, Quartile: 3.335, Q2).

Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy.
Carbone, C.; Martins-Gomes, C.; Pepe, V.; Silva, A. M.; Musumeci, T.; Puglisi, G.; Furneri, P. M.; Souto, E. B. (2018) Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy. Colloids And Surfaces B-Biointerfaces 167 :337-344. doi: 10.1016/j.colsurfb.2018.04.031. (Impact factor, Quartile: 3.997, Q1).

Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds.
Taghouti, Meriem; Martins-Gomes, Carlos; Schaefer, Judith; Felix, Luis M.; Santos, Joao A.; Bunzel, Mirko; Nunes, Fernando M.; Silva, Amelia M. (2018) Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds. Food & Function 9 (7) :3617-3629. doi: 10.1039/c8fo00456k. (Impact factor, Quartile: 3.289, Q1).

Titanium dioxide nanoparticles: Toxicity and genotoxicity in Drosophila melanogaster (SMART eye-spot test and comet assay in neuroblasts).
Sario, Sara; Silva, Amelia M.; Gaivao, Isabel (2018) Titanium dioxide nanoparticles: Toxicity and genotoxicity in Drosophila melanogaster (SMART eye-spot test and comet assay in neuroblasts). Mutation Research-Genetic Toxicology And Environmental Mutagenesis 831 :19-23. doi: 10.1016/j.mrgentox.2018.05.001. (Impact factor, Quartile: 1.996, Q3).

Influence of the stabilizers on the toxicity of metallic nanomaterials in aquatic organisms and human cell lines.
Andreani, T, Nogueira, V, Pinto, VV, Ferreira, MJ, Rasteiro, MG, Silva, AM, Pereira, R, Pereira, CM (2017) Influence of the stabilizers on the toxicity of metallic nanomaterials in aquatic organisms and human cell lines. Science Of The Total Environment 607 :1264-1277. ISSN: 0048-9697. doi: 10.1016/j.scitotenv.2017.07.098. (Impact factor, Quartile: 4.9, Q1).

Projects

Fungi4Health - Valorization of agro-industrial residues in the production of mushrooms and in the development of functional foods and value-added products (NORTE-01-0247-FEDER-070171)
Running

Coordinator  /  Ricardo Fernando de Sousa Moreira UTAD/CITAB Coordinator  /  Guilhermina Marques
Start date  /  2021/01 Funding  /  ANI - Agência Nacional de Inovação - NORTE 2020 Reference  /  NORTE-01-0247-FEDER-070171


FungiTech - Technology and innovation in the shiitake and other nutraceutical and medicinal mushrooms production chain
Concluded

UTAD/CITAB Coordinator  /  Guilhermina Marques
Start date  /  2018/07 Funding  /  Norte2020 Reference  /  NORTE-01-0247-FEDER-033788


Safe NPest: Synthesis and Environmental Safety of Nanopesticides
Concluded

Coordinator  /  Tatiana Andreani UTAD/CITAB Coordinator  /  Amélia Silva
Start date  /  2018/07 Funding  /  FCT/FEDER Reference  /  POCI-01-0145-FEDER-029343


PAIRED - Magnetically and photochemically actuated bioactive nanowires for remotely controlled drug delivery
Concluded

UTAD/CITAB Coordinator  /  Amélia Silva
Start date  /  2016/10 Funding  /  European Commission - ERA-NETS Reference  /  ERA-NET/0004/2015


INTERACT - Integrative Research in Environment, Agro-Chains and Technology
Concluded

Coordinator  /  Rui Cortes
Start date  /  2016/05 Funding  /  NORTE2020 Reference  /  NORTE-01-0145-FEDER-000017


IBERPHENOL- Cooperative research network in the field of polyphenols and their industrial applications (INTERREG 0377_Iberphenol_6_E)
Concluded

Coordinator  /  Julián Rivas Gonzal UTAD/CITAB Coordinator  /  Eduardo Rosa
Start date  /  2015/10 Funding  /  INTERREG - POCTEP (Spain - Portugal) Reference  /  INTERREG 0377_Iberphenol_6_E


SHARE OF KNOWLEDGE FOR AGRI-FOOD BY-PRODUCTS VALORISATION THROUGH INNOVATIVE SOLUTIONS TOWARD LIVESTOCK FEED AND HEALTH
Concluded

Start date  /  2015/01 Funding  /  COST (European Cooperation in Science and Technology) Reference  /  oc-2014-1-17818


Application of grape (Vitis vinifera L.) stems for livestock feed: Evaluation of nutritional, anti-inflammatory, and antimicrobial activity in vivo
Concluded

Start date  /  2015/01 Funding  /  H2020 Reference  /  SEP-210160493


INNOFOOD - INNOVation in the FOOD sector through the valorization of food and agro-food by-products
Concluded

Coordinator  /  Ana Barros
Start date  /  2014/01 Reference  /  NORTE-07-0124-FEDER-0000029


INFOGEST - Improving health properties of food by sharing our knowledge on the digestive process
Concluded

Coordinator  /  Didier Dupont UTAD/CITAB Coordinator  /  Raul Perles
Start date  /  2013/05 Funding  /  European Cooperation in Science and Technology (COST) Reference  /  COST 4198/10


Creation of Research Capacities to Increase the Competitiveness of Northern Portugal Agro-Food Companies: Added-Value Co-Products
Concluded

Coordinator  /  Eduardo Rosa UTAD/CITAB Coordinator  /  Eduardo Rosa
Start date  /  2013/01 Funding  /  European Commission Reference  /  AgriCoProd FP7-REGPOT-2012-2013-1


NanoSKIN: Nanopartículas contendo agentes quimioterapêuticos para terapias inovadoras de doenças severas da pele – Leishmaniase muco/cutânea e carcinoma espinocelular como exemplos.
Concluded

Coordinator  /  Eliana B Souto (UFP-Porto; CGB-UTAD) UTAD/CITAB Coordinator  /  Amélia Silva
Start date  /  2011/05 Reference  /  ERA-Eula/0002/2009


PromoAgro - Promoção da Competitividade Agro-alimentar
Concluded

Coordinator  /  Eduardo Rosa
Start date  /  2010/10 Funding  /  CCDRN - ON.2 Reference  /  NORTE - 07 - 0162 - FEDER - 000042


NutriDouro: Frutas confitadas e compotas saudáveis, o sabor tradicional
Concluded

Coordinator  /  Dr. Pilar Santos (Douromel) Start date  /  2010/06 Funding  /  QREN-Copromoção Reference  /  13111


Patents

Nano-hybrid technology: Efficient pesticide formulations based on hybrid nanocarriers (116935)

Patent nº /  116935

Concession date / 2023-02-20

Researchers / Amélia Silva