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Carlos A. Martins Gomes Integrated Member

BIO

Name: Carlos A. Martins Gomes

Aggregation: Integrated Member

Scopus author ID: 57200659585

Orcid ID: 0000-0002-1564-3661

Ciência Vitae: ED1C-355A-643F

Email: gomes.ma.carlos@gmail.com

Research Tasks

Innovative technologies and processes

Valorisation of bio-based products and and co-products

Publications

Labdanum Resin from Cistus ladanifer L. as a Source of Compounds with Anti-Diabetic, Neuroprotective and Anti-Proliferative Activity
Frazão D.F., Martins-Gomes C., Díaz T.S., Delgado F., Gonçalves J.C., Silva A.M., (2024) Labdanum Resin from Cistus ladanifer L. as a Source of Compounds with Anti-Diabetic, Neuroprotective and Anti-Proliferative Activity Molecules 29 (2222). ISSN: 14203049. doi: 10.3390/molecules29102222.
Linking Variability in Phytochemical Composition with Safety Profile of Thymus carnosus Boiss. Extracts: Effect of Major Compounds and Evaluation of Markers of Oxidative Stress and Cell Death
Martins-Gomes C., Nunes F.M., Silva A.M., (2024) Linking Variability in Phytochemical Composition with Safety Profile of Thymus carnosus Boiss. Extracts: Effect of Major Compounds and Evaluation of Markers of Oxidative Stress and Cell Death International Journal of Molecular Sciences 25 (5343). ISSN: 14220067. doi: 10.3390/ijms25105343.
Thymus spp. Aqueous Extracts and Their Constituent Salvianolic Acid A Induce Nrf2-Dependent Cellular Antioxidant Protection Against Oxidative Stress in Caco-2 Cells
Martins-Gomes C., Nunes F.M., Silva A.M., (2024) Thymus spp. Aqueous Extracts and Their Constituent Salvianolic Acid A Induce Nrf2-Dependent Cellular Antioxidant Protection Against Oxidative Stress in Caco-2 Cells Antioxidants 13 (1287). ISSN: 20763921. doi: 10.3390/antiox13111287.
Cell penetrating peptides-functionalized Licochalcone-A-loaded PLGA nanoparticles for ocular inflammatory diseases: Evaluation of in vitro anti-proliferative effects, stabilization by freeze-drying and characterization of an in-situ forming gel
Galindo-Camacho R.M., Haro I., Gómara M.J., Espina M., Fonseca J., Martins-Gomes C., Camins A., Silva A.M., García M.L., Souto E.B., (2023) Cell penetrating peptides-functionalized Licochalcone-A-loaded PLGA nanoparticles for ocular inflammatory diseases: Evaluation of in vitro anti-proliferative effects, stabilization by freeze-drying and characterization of an in-situ forming gel International Journal of Pharmaceutics 639 (122982). ISSN: 18733476. doi: 10.1016/j.ijpharm.2023.122982.
Combining Zeolites with Early-Maturing Annual Legume Cover Crops in Rainfed Orchards: Effects on Yield, Fatty Acid Composition and Polyphenolic Profile of Olives and Olive Oil
Martins S., Silva E., Brito C., Pinto L., Martins-Gomes C., Gonçalves A., Arrobas M., Rodrigues M.Â., Correia C.M., Nunes F.M., (2023) Combining Zeolites with Early-Maturing Annual Legume Cover Crops in Rainfed Orchards: Effects on Yield, Fatty Acid Composition and Polyphenolic Profile of Olives and Olive Oil Molecules 28 (2545). ISSN: 14203049. doi: 10.3390/molecules28062545.
Modulation of Cell Death Pathways for Cellular Protection and Anti-Tumoral Activity: The Role of Thymus spp. Extracts and Their Bioactive Molecules
Martins-Gomes C., Nunes F.M., Silva A.M., (2023) Modulation of Cell Death Pathways for Cellular Protection and Anti-Tumoral Activity: The Role of Thymus spp. Extracts and Their Bioactive Molecules International Journal of Molecular Sciences 24 (1691). ISSN: 14220067. doi: 10.3390/ijms24021691.
Molecular Characterization of Prunus lusitanica L. Fruit Extracts and Their Health-Promoting Potential in Inflammation, Diabetes, and Neurodegenerative Diseases
Abraão A., Martins-Gomes C., Domínguez-Perles R., Barros A., Silva A.M., (2023) Molecular Characterization of Prunus lusitanica L. Fruit Extracts and Their Health-Promoting Potential in Inflammation, Diabetes, and Neurodegenerative Diseases International Journal of Molecular Sciences 24 (8830). ISSN: 14220067. doi: 10.3390/ijms24108830.
Natural Products as a Tool to Modulate the Activity and Expression of Multidrug Resistance Proteins of Intestinal Barrier
Martins-Gomes C., Silva A.M., (2023) Natural Products as a Tool to Modulate the Activity and Expression of Multidrug Resistance Proteins of Intestinal Barrier Journal of Xenobiotics 13 :172-192. ISSN: 20394713. doi: 10.3390/jox13020014.
Phytochemical Composition and Antioxidant, Anti-Acetylcholinesterase, and Anti-α-Glucosidase Activity of Thymus carnosus Extracts: A Three-Year Study on the Impact of Annual Variation and Geographic Location
Martins-Gomes C., Steck J., Keller J., Bunzel M., Santos J.A., Nunes F.M., Silva A.M., (2023) Phytochemical Composition and Antioxidant, Anti-Acetylcholinesterase, and Anti-α-Glucosidase Activity of Thymus carnosus Extracts: A Three-Year Study on the Impact of Annual Variation and Geographic Location Antioxidants 12 (668). ISSN: 20763921. doi: 10.3390/antiox12030668.
Elderberry (Sambucus nigra L.) extracts promote anti-inflammatory and cellular antioxidant activity
Ferreira S.S., Martins-Gomes C., Nunes F.M., Silva A.M., (2022) Elderberry (Sambucus nigra L.) extracts promote anti-inflammatory and cellular antioxidant activity Food Chemistry: X 15 (100437). ISSN: 25901575. doi: 10.1016/j.fochx.2022.100437.
Glyphosate vs. Glyphosate-Based Herbicides Exposure: A Review on Their Toxicity
Martins-Gomes C., Silva T.L., Andreani T., Silva A.M., (2022) Glyphosate vs. Glyphosate-Based Herbicides Exposure: A Review on Their Toxicity Journal of Xenobiotics 12 :21-40. ISSN: 20394713. doi: 10.3390/jox12010003.
In Vitro Assessment of Pesticides Toxicity and Data Correlation with Pesticides Physicochemical Properties for Prediction of Toxicity in Gastrointestinal and Skin Contact Exposure
Silva A.M., Martins-Gomes C., Silva T.L., Coutinho T.E., Souto E.B., Andreani T., (2022) In Vitro Assessment of Pesticides Toxicity and Data Correlation with Pesticides Physicochemical Properties for Prediction of Toxicity in Gastrointestinal and Skin Contact Exposure Toxics 10 (378). ISSN: 23056304. doi: 10.3390/toxics10070378.
Labdanum Resin from Cistus ladanifer L.: A Natural and Sustainable Ingredient for Skin Care Cosmetics with Relevant Cosmeceutical Bioactivities
Frazão D.F., Martins-Gomes C., Steck J.L., Keller J., Delgado F., Gonçalves J.C., Bunzel M., Pintado C.M.B.S., Díaz T.S., Silva A.M., (2022) Labdanum Resin from Cistus ladanifer L.: A Natural and Sustainable Ingredient for Skin Care Cosmetics with Relevant Cosmeceutical Bioactivities Plants 11 (1477). ISSN: 22237747. doi: 10.3390/plants11111477.
Lipid-Drug Conjugates and Nanoparticles for the Cutaneous Delivery of Cannabidiol
Zielińska A., Cano A., Andreani T., Martins-Gomes C., Silva A.M., Szalata M., Słomski R., Souto E.B., (2022) Lipid-Drug Conjugates and Nanoparticles for the Cutaneous Delivery of Cannabidiol International Journal of Molecular Sciences 23 (6165). ISSN: 14220067. doi: 10.3390/ijms23116165.
Microemulsions and Nanoemulsions in Skin Drug Delivery
Souto E.B., Cano A., Martins-Gomes C., Coutinho T.E., Zielińska A., Silva A.M., (2022) Microemulsions and Nanoemulsions in Skin Drug Delivery Bioengineering 9 (158). ISSN: 23065354. doi: 10.3390/bioengineering9040158.
Molecular Characterization of Thymus capitellatus Extracts and Their Antioxidant, Neuroprotective and Anti-Proliferative Activities
Martins-Gomes C., Steck J., Keller J., Bunzel M., Nunes F.M., Silva A.M., (2022) Molecular Characterization of Thymus capitellatus Extracts and Their Antioxidant, Neuroprotective and Anti-Proliferative Activities International Journal of Molecular Sciences 23 (15187). ISSN: 14220067. doi: 10.3390/ijms232315187.
Molecular Physicochemical Properties of Selected Pesticides as Predictive Factors for Oxidative Stress and Apoptosis-Dependent Cell Death in Caco-2 and HepG2 Cells
Silva A.M., Martins-Gomes C., Ferreira S.S., Souto E.B., Andreani T., (2022) Molecular Physicochemical Properties of Selected Pesticides as Predictive Factors for Oxidative Stress and Apoptosis-Dependent Cell Death in Caco-2 and HepG2 Cells International Journal of Molecular Sciences 23 (8107). ISSN: 14220067. doi: 10.3390/ijms23158107.
Nanophytosomes: a novel approach for the delivery of herbal drugs
Martins-Gomes C., Souto E.B., Silva A.M., (2022) Nanophytosomes: a novel approach for the delivery of herbal drugs Systems of Nanovesicular Drug Delivery :239-257. doi: 10.1016/B978-0-323-91864-0.00015-2.
Neurotoxicity Assessment of Four Different Pesticides Using In Vitro Enzymatic Inhibition Assays
Martins-Gomes C., Coutinho T.E., Silva T.L., Andreani T., Silva A.M., (2022) Neurotoxicity Assessment of Four Different Pesticides Using In Vitro Enzymatic Inhibition Assays Toxics 10 (448). ISSN: 23056304. doi: 10.3390/toxics10080448.
Zeolites and Biochar Modulate Olive Fruit and Oil Polyphenolic Profile
Martins S., Silva E., Brito C., Martins-Gomes C., Gonçalves A., Arrobas M., Rodrigues M.Â., Correia C.M., Nunes F.M., (2022) Zeolites and Biochar Modulate Olive Fruit and Oil Polyphenolic Profile Antioxidants 11 (1332). ISSN: 20763921. doi: 10.3390/antiox11071332.
Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
Silva A.M., Félix L.M., Teixeira I., Martins-Gomes C., Schäfer J., Souto E.B., Santos D.J., Bunzel M., Nunes F.M., (2021) Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits Food Chemistry: X 12 (100171). ISSN: 25901575. doi: 10.1016/j.fochx.2021.100171.
Red seaweeds strengthening the nexus between nutrition and health: phytochemical characterization and bioactive properties of Grateloupia turuturu and Porphyra umbilicalis extracts
Ferreira J., Hartmann A., Martins-Gomes C., Nunes F.M., Souto E.B., Santos D.L., Abreu H., Pereira R., Pacheco M., Gaivão I., Silva A.M., (2021) Red seaweeds strengthening the nexus between nutrition and health: phytochemical characterization and bioactive properties of Grateloupia turuturu and Porphyra umbilicalis extracts Journal of Applied Phycology 33 :3365-3381. ISSN: 15735176. doi: 10.1007/s10811-021-02529-6.
Chemical characterization and bioactivity of extracts from Thymus mastichina: A thymus with a distinct salvianolic acid composition
Taghouti M., Martins-Gomes C., Schäfer J., Santos J.A., Bunzel M., Nunes F.M., Silva A.M., (2020) Chemical characterization and bioactivity of extracts from Thymus mastichina: A thymus with a distinct salvianolic acid composition Antioxidants 9 (34). ISSN: 20763921. doi: 10.3390/antiox9010034.
Diabetic retinopathy and ocular melanoma: How far we are?
Souto E.B., Campos J.R., Da Ana R., Fangueiro J.F., Martins-Gomes C., Durazzo A., Lucarini M., López E.S., Espina M., García M.L., Silva A.M., Mendonça F., Santini A., Souto S.B., (2020) Diabetic retinopathy and ocular melanoma: How far we are? Applied Sciences (Switzerland) 10 (2777). ISSN: 20763417. doi: 10.3390/APP10082777.
Nanomaterials for skin delivery of cosmeceuticals and pharmaceuticals
Souto E.B., Fernandes A.R., Martins-Gomes C., Coutinho T.E., Durazzo A., Lucarini M., Souto S.B., Silva A.M., Santini A., (2020) Nanomaterials for skin delivery of cosmeceuticals and pharmaceuticals Applied Sciences (Switzerland) 10 (1594). ISSN: 20763417. doi: 10.3390/app10051594.
Ocular cell lines and genotoxicity assessment
Souto E.B., Campos J.R., Da Ana R., Martins-Gomes C., Silva A.M., Souto S.B., Lucarini M., Durazzo A., Santini A., (2020) Ocular cell lines and genotoxicity assessment International Journal of Environmental Research and Public Health 17 (2046). ISSN: 16604601. doi: 10.3390/ijerph17062046.
Polyphenol composition and biological activity of Thymus citriodorus and Thymus vulgaris: Comparison with endemic Iberian Thymus species
Taghouti M., Martins-Gomes C., Félix L.M., Schäfer J., Santos J.A., Bunzel M., Nunes F.M., Silva A.M., (2020) Polyphenol composition and biological activity of Thymus citriodorus and Thymus vulgaris: Comparison with endemic Iberian Thymus species Food Chemistry 331 (127362). ISSN: 18737072. doi: 10.1016/j.foodchem.2020.127362.
Thymus zygis subsp. zygis an endemic portuguese plant: Phytochemical profiling, antioxidant, anti-proliferative and anti-inflammatory activities
Silva A.M., Martins-Gomes C., Souto E.B., Schäfer J., Santos J.A., Bunzel M., Nunes F.M., (2020) Thymus zygis subsp. zygis an endemic portuguese plant: Phytochemical profiling, antioxidant, anti-proliferative and anti-inflammatory activities Antioxidants 9 (482). ISSN: 20763921. doi: 10.3390/antiox9060482.
3D printing in the design of pharmaceutical dosage forms
Souto E.B., Campos J.C., Filho S.C., Teixeira M.C., Martins-Gomes C., Zielinska A., Carbone C., Silva A.M., (2019) 3D printing in the design of pharmaceutical dosage forms Pharmaceutical Development and Technology 24 :1044-1053. ISSN: 10979867. doi: 10.1080/10837450.2019.1630426.
Clotrimazole-loaded mediterranean essential oils NLC: A synergic treatment of Candida skin infections
Carbone C., Teixeira M.D.C., Sousa M.D.C., Martins-Gomes C., Silva A.M., Souto E.M.B., Musumeci T., (2019) Clotrimazole-loaded mediterranean essential oils NLC: A synergic treatment of Candida skin infections Pharmaceutics 11 (231). ISSN: 19994923. doi: 10.3390/pharmaceutics11050231.
Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines
Silva A.M., Martins-Gomes C., Fangueiro J.F., Andreani T., Souto E.B., (2019) Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines Pharmaceutical Development and Technology 24 :1243-1249. ISSN: 10979867. doi: 10.1080/10837450.2019.1658774.
Ginkgo biloba L. Leaf extract protects HepG2 cells against paraquat-induced oxidative DNA damage
Silva A.M., Silva S.C., Soares J.P., Martins-Gomes C., Teixeira J.P., Leal F., Gaivão I., (2019) Ginkgo biloba L. Leaf extract protects HepG2 cells against paraquat-induced oxidative DNA damage Plants 8 (556). ISSN: 22237747. doi: 10.3390/plants8120556.
In vitro cytotoxicity of oleanolic/ursolic acids-loaded in PLGA nanoparticles in different cell lines
Silva A.M., Alvarado H.L., Abrego G., Martins-Gomes C., Garduño-Ramirez M.L., García M.L., Calpena A.C., Souto E.B., (2019) In vitro cytotoxicity of oleanolic/ursolic acids-loaded in PLGA nanoparticles in different cell lines Pharmaceutics 11 (362). ISSN: 19994923. doi: 10.3390/pharmaceutics11080362.
Myasthenia gravis: State of the art and new therapeutic strategies
Souto E.B., Lima B., Campos J.R., Martins-Gomes C., Souto S.B., Silva A.M., (2019) Myasthenia gravis: State of the art and new therapeutic strategies Journal of Neuroimmunology 337 (577080). ISSN: 18728421. doi: 10.1016/j.jneuroim.2019.577080.
Polyphenols for skin cancer: Chemical properties, structure-related mechanisms of action and new delivery systems
Souto E., Sampaio A., Campos J., Martins-Gomes C., Aires A., Silva A., (2019) Polyphenols for skin cancer: Chemical properties, structure-related mechanisms of action and new delivery systems Studies in Natural Products Chemistry 63 :21-42. ISBN: 9780128179017. doi: 10.1016/B978-0-12-817901-7.00002-2.
Rosmarinic Acid: Sources, Bioactivities and Health Benefits.
Martins-Gomes, Carlos; Nunes, Fernando M.; Sampaio, Ana C.; Souto, Eliana B.; Silva, Amélia M. (2019) Rosmarinic Acid: Sources, Bioactivities and Health Benefits. IN: Ryan, Iman (Ed.) Phytochemicals: Plant Sources and Potential Health Benefits. Book Series: Plant Science Research and Practices. NovaScience Publishers, New York, USA (Chapter 4) :109-146. ISBN: 978-1-53615-478-8.
Soft cationic nanoparticles for drug delivery: Production and cytotoxicity of solid lipid nanoparticles (SLNs)
Silva A.M., Martins-Gomes C., Coutinho T.E., Fangueiro J.F., Sanchez-Lopez E., Pashirova T.N., Andreani T., Souto E.B., (2019) Soft cationic nanoparticles for drug delivery: Production and cytotoxicity of solid lipid nanoparticles (SLNs) Applied Sciences (Switzerland) 9 (4438). ISSN: 20763417. doi: 10.3390/app9204438.
The influence of polysaccharide coating on the physicochemical parameters and cytotoxicity of silica nanoparticles for hydrophilic biomolecules delivery
Andreani T., Fangueiro J., Severino P., de Souza A., Martins-Gomes C., Fernandes P., Calpena A., Gremião M., Souto E., Silva A., (2019) The influence of polysaccharide coating on the physicochemical parameters and cytotoxicity of silica nanoparticles for hydrophilic biomolecules delivery Nanomaterials 9 (1081). ISSN: 20794991. doi: 10.3390/nano9081081.
Thymus carnosus extracts induce anti-proliferative activity in Caco-2 cells through mechanisms that involve cell cycle arrest and apoptosis
Martins-Gomes C., Souto E.B., Cosme F., Nunes F.M., Silva A.M., (2019) Thymus carnosus extracts induce anti-proliferative activity in Caco-2 cells through mechanisms that involve cell cycle arrest and apoptosis Journal of Functional Foods 54 :128-135. doi: 10.1016/j.jff.2019.01.010.
Trends in atopic dermatitis—from standard pharmacotherapy to novel drug delivery systems
Souto E.B., Dias-Ferreira J., Oliveira J., Sanchez-Lopez E., Lopez-Machado A., Espina M., Garcia M.L., Souto S.B., Martins-Gomes C., Silva A.M., (2019) Trends in atopic dermatitis—from standard pharmacotherapy to novel drug delivery systems International Journal of Molecular Sciences 20 (5659). ISSN: 14220067. doi: 10.3390/ijms20225659.
Uveal melanoma: physiopathology and new in situ-specific therapies
Souto E.B., Zielinska A., Luis M., Carbone C., Martins-Gomes C., Souto S.B., Silva A.M., (2019) Uveal melanoma: physiopathology and new in situ-specific therapies Cancer Chemotherapy and Pharmacology 84 :15-32. ISSN: 14320843. doi: 10.1007/s00280-019-03860-z.
Anti-inflammatory and Anti-cancer Activity of Citral: Optimization of Citral-loaded Solid Lipid Nanoparticles (SLN) using Experimental Factorial Design and LUMiSizer.
Zielińska, Alexandra; Martins-Gomes, Carlos; Ferreira, Nuno R. ; Silva, Amélia M.; Nowak, I.; Souto, Eliana B. (2018) Anti-inflammatory and Anti-cancer Activity of Citral: Optimization of Citral-loaded Solid Lipid Nanoparticles (SLN) using Experimental Factorial Design and LUMiSizer. INTERNATIONAL JOURNAL OF PHARMACEUTICS 553 (2-Jan) :428-440. doi: 10.1016/j.ijpharm.2018.10.065. (Impact factor, Quartile: 3.862, Q1).
Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss.
Martins-Gomes, Carlos; Taghouti, Meriem; Schaefer, Judith; Bunzel, Mirko; Silva, Amelia M.; Nunes, Fernando M. (2018) Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss. Journal Of Functional Foods 43 :154-164. doi: 10.1016/j.jff.2018.02.012. (Impact factor, Quartile: 3.47, Q1).
Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles.
Carbone, C.; Martins-Gomes, C.; Caddeo, C.; Silva, A. M.; Musumeci, T.; Pignatello, R.; Puglisi, G.; Souto, E. B. (2018) Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles. International Journal Of Pharmaceutics 548 (1) :217-226. doi: 10.1016/j.ijpharm.2018.06.064. (Impact factor, Quartile: 3.862, Q1).
Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy.
Carbone, C.; Martins-Gomes, C.; Pepe, V.; Silva, A. M.; Musumeci, T.; Puglisi, G.; Furneri, P. M.; Souto, E. B. (2018) Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy. Colloids And Surfaces B-Biointerfaces 167 :337-344. doi: 10.1016/j.colsurfb.2018.04.031. (Impact factor, Quartile: 3.997, Q1).
Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds.
Taghouti, Meriem; Martins-Gomes, Carlos; Schaefer, Judith; Felix, Luis M.; Santos, Joao A.; Bunzel, Mirko; Nunes, Fernando M.; Silva, Amelia M. (2018) Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds. Food & Function 9 (7) :3617-3629. doi: 10.1039/c8fo00456k. (Impact factor, Quartile: 3.289, Q1).