Researcher - CITAB

Exploring the Chemopreventive and Antioxidant Effects of Spearmint Leaf Hydroethanolic Extract in HPV16‐transgenic Mice

Jesus T.M., Azevedo T., Silva‐Reis R., Ferreira T., Nascimento‐Gonçalves E., Medeiros C., Ferreira J., Gama A., Gaivão I., Pires M.J., Lanzarin G., Félix L., Venâncio C., Medeiros R., Bastos M.M.S.M., Finimundy T.C., Barros L., Gil Da Costa R.M., Oliveira P.A., (2025) Exploring the Chemopreventive and Antioxidant Effects of Spearmint Leaf Hydroethanolic Extract in HPV16‐transgenic Mice In Vivo 39 :1303-1313. ISSN: 17917549. doi: 10.21873/invivo.13934.

The Impact of a Western Diet and Resistance Training in a Rat Model of Mammary Cancer

Silva J., Azevedo T., Ferreira R., Neuparth M.J., Seixas F., Ginja M., Pires M.J., Faustino-Rocha A.I., Duarte J.A., Oliveira P.A., (2025) The Impact of a Western Diet and Resistance Training in a Rat Model of Mammary Cancer Life 15 (250). ISSN: 20751729. doi: 10.3390/life15020250.

Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesions: findings from K14-HPV16 mice

Medeiros-Fonseca B., Faustino-Rocha A.I., Silva J., Silva M.G., Pires M.J., Neuparth M.J., Vala H., Vasconcelos-Nóbrega C., Dias M.I., Barros L., Gonçalves L., Gaivão I., Bastos M.M.S.M., Félix L., Venâncio C., Medeiros R., Gil da Costa R.M., Oliveira P.A., (2024) Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesions: findings from K14-HPV16 mice Exploration of Medicine 5 :416-433. ISSN: 26923106. doi: 10.37349/emed.2024.00228.

Exploring the therapeutic potential of Quercus ilex acorn extract in papillomavirus-induced lesions

Medeiros-Fonseca B., Faustino-Rocha A.I., Pires M.J., Neuparth M.J., Vala H., Vasconcelos-Nóbrega C., Gouvinhas I., Barros A.N., Dias M.I., Barros L., Bastos M.M.S.M., Gonçalves L., Félix L., Venâncio C., Medeiros R., da Costa R.M.G., Oliveira P.A., (2024) Exploring the therapeutic potential of Quercus ilex acorn extract in papillomavirus-induced lesions Veterinary World 17 :2644-2658. ISSN: 22310916. doi: 10.14202/vetworld.2024.2644-2658.

Lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of prostate carcinogenesis

Nascimento-Gonçalves E., Seixas F., Palmeira C., Martins G., Fonseca C., Duarte J.A., Faustino-Rocha A.I., Colaço B., Pires M.J., Neuparth M.J., Moreira-Gonçalves D., Fardilha M., Henriques M.C., Patrício D., Pelech S., Ferreira R., Oliveira P.A., (2024) Lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of prostate carcinogenesis GeroScience 46 :817-840. ISSN: 25092723. doi: 10.1007/s11357-023-00806-5.

The Effect of Lemon Juice (Citrus limon L.) Treated with Melatonin on the Health Status and Treatment of K14HPV16 Mice

Badiche-El Hilali F., Medeiros-Fonseca B., Silva J., Silvestre-Ferreira A.C., Pires M.J., Gil da Costa R.M., Peixoto F., Oliveira P.A., Valero D., (2024) The Effect of Lemon Juice (Citrus limon L.) Treated with Melatonin on the Health Status and Treatment of K14HPV16 Mice Antioxidants 13 (588). ISSN: 20763921. doi: 10.3390/antiox13050588.

The role of natural compounds in rat mammary cancer: the beneficial effects of Santolina chamaecyparissus L. aqueous extract

Azevedo T., Silva J., Faustino-Rocha A.I., Valada A., Anjos L., Moura T., Ferreira R., Santos M., Pires M.J., Neuparth M.J., Peixoto F., Silvestre-Ferreira A.C., Gama A., Seixas F., Finimundy T.C., Barros L., Matos M., Oliveira P.A., (2024) The role of natural compounds in rat mammary cancer: the beneficial effects of Santolina chamaecyparissus L. aqueous extract Veterinarska Stanica 55 :45-61. ISSN: 18491170. doi: 10.46419/vs.55.1.3.

Animal Models in Phytopharmacology and Toxicological Testing of Plant Products

Faustino-Rocha A.I., Medeiros-Fonseca B., Vala H., Pires M.J., Vasconcelos-Nóbrega C., Oliveira P.A., (2023) Animal Models in Phytopharmacology and Toxicological Testing of Plant Products Ethnobotany and Ethnopharmacology of Medicinal and Aromatic Plants: Steps Towards Drug Discovery :289-306. doi: 10.1201/b22842-16.

Appraising Animal Models of Prostate Cancer for Translational Research: Future Directions

Nascimento-Goncalves E., Seixas F., Gil Da Costa R.M., Pires M.J., Neuparth M.J., Moreira-Goncalves D., Fardilha M., Faustino-Rocha A.I., Colaco B., Ferreira R., Oliveira P.A., (2023) Appraising Animal Models of Prostate Cancer for Translational Research: Future Directions Anticancer Research 43 :275-281. ISSN: 17917530. doi: 10.21873/anticanres.16160.

Cytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus-induced neoplasia

Medeiros C., Silva A.R., Ferreira T., Barros L., Neuparth M.J., Peixoto F., Bastos M.M.S.M., Medeiros R., Gil da Costa R.M., Pires M.J., Faustino-Rocha A.I., Gama A., Oliveira P.A., (2023) Cytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus-induced neoplasia Veterinarska Stanica 54 :637-653. ISSN: 18491170. doi: 10.46419/vs.54.6.9.

Quercus spp. extract as a promising preventive or therapeutic strategy for cancer: A systematic review

Oliveira P.A., Medeiros-Fonseca B., Vasconcelos-Nóbrega C., Alvarado A., Pires M.J., Vala H., Barros A.I.R.N.A., Faustino-Rocha A.I., (2023) Quercus spp. extract as a promising preventive or therapeutic strategy for cancer: A systematic review Molecular Medicine Reports 28 (175). ISSN: 17913004. doi: 10.3892/mmr.2023.13062.

Study on the antineoplastic and toxicological effects of pomegranate (Punica granatum L.) leaf infusion using the K14-HPV16 transgenic mouse model

Yu M., Gouvinhas I., Pires M.J., Neuparth M.J., Costa R.M.G.d., Medeiros R., Bastos M.M.S.M., Vala H., Félix L., Venâncio C., Barros A.I.R.N.A., Oliveira P.A., (2023) Study on the antineoplastic and toxicological effects of pomegranate (Punica granatum L.) leaf infusion using the K14-HPV16 transgenic mouse model Food and Chemical Toxicology 174 (113689). ISSN: 18736351. doi: 10.1016/j.fct.2023.113689.

An Integrative Approach to Characterize the Early Phases of Dimethylhydrazine‐Induced Colorectal Carcinogenesis in the Rat

Silva‐reis R., Castro-Ribeiro C., Gonçalves M., Ferreira T., Pires M.J., Iglesias‐aguirre C.E., Cortés‐martín A., Selma M.V., Espín J.C., Nascimento‐gonçalves E., Moreira‐pais A., Neuparth M.J., Peixoto F., Rosa E., Gama A., Ferreira R., Oliveira P.A., Faustino‐rocha A.I., (2022) An Integrative Approach to Characterize the Early Phases of Dimethylhydrazine‐Induced Colorectal Carcinogenesis in the Rat Biomedicines 10 (409). ISSN: 22279059. doi: 10.3390/biomedicines10020409.

Beneficial Effects of Broccoli (Brassica oleracea var italica) By-products in Diet-induced Obese Mice

Martins T., Leite R., Matos A.F., Soares J., Pires M.J., de Lurdes Pinto M., Neuparth M.J., Sequeira A.R., Félix L., Venâncio C., Monteiro S.M., Colaço B., Gouvinhas I., Barros A.I., Rosa E., Oliveira P.A., Antunes L.M., (2022) Beneficial Effects of Broccoli (Brassica oleracea var italica) By-products in Diet-induced Obese Mice In Vivo 36 :2173-2185. ISSN: 17917549. doi: 10.21873/invivo.12943.

Comparison of Gelatin Flavors for Oral Dosing of C57BL/6J and FVB/N Mice

Martins T., Matos A.F., Soares J., Leite R., Pires M.J., Ferreira T., Medeiros-Fonseca B., Rosa E., Oliveira P.A., Antunes L.M., (2022) Comparison of Gelatin Flavors for Oral Dosing of C57BL/6J and FVB/N Mice Journal of the American Association for Laboratory Animal Science 61 :89-95. doi: 10.30802/AALAS-JAALAS-21-000045.

Effect of a Sub-Chronic Oral Exposure of Broccoli (Brassica oleracea L. Var. Italica) By-Products Flour on the Physiological Parameters of FVB/N Mice: A Pilot Study

Martins T., Oliveira P.A., Pires M.J., Neuparth M.J., Lanzarin G., Félix L., Venâncio C., Pinto M.d.L., Ferreira J., Gaivão I., Barros A.I., Rosa E., Antunes L.M., (2022) Effect of a Sub-Chronic Oral Exposure of Broccoli (Brassica oleracea L. Var. Italica) By-Products Flour on the Physiological Parameters of FVB/N Mice: A Pilot Study Foods 11 (120). ISSN: 23048158. doi: 10.3390/foods11010120.

Genoprotection and metabolic benefits of marine macroalgae - Insights into the concept of functional foods through direct and indirect consumption

Marques A., Ferreira J., Cerqueda-Pacheco A., Pereira V., Abreu H., Pereira R., Pires M.J., Seixas F., Oliveira P., Gaivão I., Pacheco M., (2022) Genoprotection and metabolic benefits of marine macroalgae - Insights into the concept of functional foods through direct and indirect consumption Food Bioscience 47 (101649). ISSN: 22124306. doi: 10.1016/j.fbio.2022.101649.

Pulegone and Eugenol Oral Supplementation in Laboratory Animals: Results from Acute and Chronic Studies

Ribeiro-Silva C.M., Faustino-Rocha A.I., Gil da Costa R.M., Medeiros R., Pires M.J., Gaivão I., Gama A., Neuparth M.J., Barbosa J.V., Peixoto F., Magalhães F.D., Bastos M.M.S.M., Oliveira P.A., (2022) Pulegone and Eugenol Oral Supplementation in Laboratory Animals: Results from Acute and Chronic Studies Biomedicines 10 (2595). ISSN: 22279059. doi: 10.3390/biomedicines10102595.

Supplementation of an Anthocyanin-Rich Elderberry (Sambucus nigra L.) Extract in FVB/n Mice: A Healthier Alternative to Synthetic Colorants

Azevedo T., Ferreira T., Ferreira J., Teixeira F., Ferreira D., Silva-Reis R., Neuparth M.J., Pires M.J., Pinto M.d.L., Gil da Costa R.M., Bastos M.M.S.M., Medeiros R., Félix L., Venâncio C., Dias M.I., Gaivão I., Barros L., Oliveira P.A., (2022) Supplementation of an Anthocyanin-Rich Elderberry (Sambucus nigra L.) Extract in FVB/n Mice: A Healthier Alternative to Synthetic Colorants Applied Sciences (Switzerland) 12 (11928). ISSN: 20763417. doi: 10.3390/app122311928.

The red seaweed grateloupia turuturu prevents epidermal dysplasia in hpv16-transgenic mice

Almeida J., Ferreira T., Santos S., Pires M.J., da Costa R.M.G., Medeiros R., Bastos M.M.S.M., Neuparth M.J., Faustino-Rocha A.I., Abreu H., Pereira R., Pacheco M., Gaivão I., Rosa E., Oliveira P.A., (2021) The red seaweed grateloupia turuturu prevents epidermal dysplasia in hpv16-transgenic mice Nutrients 13 (4529). ISSN: 20726643. doi: 10.3390/nu13124529.

Toxicological and anti-tumor effects of a linden extract (: Tilia platyphyllos Scop.) in a HPV16-transgenic mouse model

Ferreira T., Nascimento-Gonçalves E., Macedo S., Borges I., Gama A., M. Gil Da Costa R., Neuparth M.J., Lanzarin G., Venâncio C., Félix L., Gaivão I., Alvarado A., Pires M.J., Bastos M.M.S.M., Medeiros R., Nogueira A., Barros L., Ferreira I.C.F.R., Rosa E., Oliveira P.A., (2021) Toxicological and anti-tumor effects of a linden extract (: Tilia platyphyllos Scop.) in a HPV16-transgenic mouse model Food and Function 12 :4005-4014. ISSN: 2042650X. doi: 10.1039/d1fo00225b.

Dietary supplementation with chestnut (Castanea sativa) reduces abdominal adiposity in FVB/n mice: A preliminary study

Rodrigues P., Ferreira T., Nascimento-Gonçalves E., Seixas F., da Costa R.M.G., Martins T., Neuparth M.J., Pires M.J., Lanzarin G., Félix L., Venâncio C., Ferreira I.C.F.R., Bastos M.M.S.M., Medeiros R., Gaivão I., Rosa E., Oliveira P.A., (2020) Dietary supplementation with chestnut (Castanea sativa) reduces abdominal adiposity in FVB/n mice: A preliminary study Biomedicines 8 (75). ISSN: 22279059. doi: 10.3390/biomedicines8040075.

Ultrasonographic Follow-up of the Multistep Protocol for Prostate Cancer Induction in Wistar Rats

Faustino-Rocha A.I., Seixas F., Ferreira R., Silva J., Pires M.J., Fardilha M., Ginja M., Oliveira P.A., (2020) Ultrasonographic Follow-up of the Multistep Protocol for Prostate Cancer Induction in Wistar Rats In Vivo 34 :1797-1803. ISSN: 17917549. doi: 10.21873/invivo.11974.

Anatomy and imaging of rat prostate: Practical monitoring in experimental cancer-induced protocols

Ginja M., Pires M.J., Gonzalo-Orden J.M., Seixas F., Correia-Cardoso M., Ferreira R., Fardilha M., Oliveira P.A., Faustino-Rocha A.I., (2019) Anatomy and imaging of rat prostate: Practical monitoring in experimental cancer-induced protocols Diagnostics 9 (68). ISSN: 20754418. doi: 10.3390/diagnostics9030068.

Dietary supplementation with the red seaweed porphyra umbilicalis protects against DNA damage and pre-malignant dysplastic skin lesions in HPV-transgenic mice

Santos S., Ferreira T., Almeida J., Pires M.J., Colaço A., Lemos S., Da Costa R.M.G., Medeiros R., Bastos M.M.S.M., Neuparth M.J., Abreu H., Pereira R., Pacheco M., Gaivão I., Rosa E., Oliveira P.A., (2019) Dietary supplementation with the red seaweed porphyra umbilicalis protects against DNA damage and pre-malignant dysplastic skin lesions in HPV-transgenic mice Marine Drugs 17 (615). ISSN: 16603397. doi: 10.3390/md17110615.

The cyclooxigenase-2 inhibitor parecoxib prevents epidermal dysplasia in HPV16-transgenic mice: efficacy and safety observations

Ferreira T., Campos S., Silva M.G., Ribeiro R., Santos S., Almeida J., Pires M.J., da Costa R.M.G., Córdova C., Nogueira A., Neuparth M.J., Medeiros R., Bastos M.M.d.S.M., Gaivão I., Peixoto F., Oliveira M.M., Oliveira P.A., (2019) The cyclooxigenase-2 inhibitor parecoxib prevents epidermal dysplasia in HPV16-transgenic mice: efficacy and safety observations International Journal of Molecular Sciences 20 (3902). ISSN: 14220067. doi: 10.3390/ijms20163902.

Assessment of the exposure to heavy metals and arsenic in captive and freeliving black kites (Milvus migrans) nesting in Portugal.

Carneiro, M.; Oliveira, P.A.; Brandão, R.; Soeiro, V.; Pires, M.J.; Lavin, S.; Colaço, B. (2018) Assessment of the exposure to heavy metals and arsenic in captive and freeliving black kites (Milvus migrans) nesting in Portugal. Ecotoxicology And Environmental Safety 160 :191-196. doi: 10.1016/j.ecoenv.2018.05.040. (Impact factor, Quartile: 3.974, Q1).

Exercise training protects against cancer-induced cardiac remodeling in an animal model of urothelial carcinoma.

Padrao, Ana Isabel; Nogueira-Ferreira, Rita; Vitorino, Rui; Carvalho, Dulce; Correia, Catarina; Neuparth, Maria Joao; Pires, Maria Joao; Faustino-Rocha, Ana Isabel; Santos, Lucio Lara; Oliveira, Paula Alexandra; Duarte, Jose Alberto; Moreira-Goncalves, Daniel; Ferreira, Rita (2018) Exercise training protects against cancer-induced cardiac remodeling in an animal model of urothelial carcinoma. Archives Of Biochemistry And Biophysics 645 :43435. doi: 10.1016/j.abb.2018.03.013. (Impact factor, Quartile: 3.118, Q2).

Laurus nobilis (laurel) aqueous leaf extract's toxicological and anti-tumor activities in HPV16-transgenic mice.

Medeiros-Fonseca, B; Mestre, VF; Colaço, B; Pires, MJ; Martins, T; Gil da Costa, RM; Neuparth, MJ; Medeiros, R; Moutinho, MSS; Dias, MI; Barros, L; Bastos, MMSM; Félix, L; Venâncio, C; Ferreira, ICFR; Antunes, LM; Oliveira, PA. (2018) Laurus nobilis (laurel) aqueous leaf extract's toxicological and anti-tumor activities in HPV16-transgenic mice. FOOD & FUNCTION 9 :4419-4428. doi: 10.1039/c8fo00783g. (Impact factor, Quartile: 3.289, Q1).

Ozone therapy prevents the onset of dysplasia in HPV16-transgenic mice-A pre-clinical efficacy and safety analysis.

Peirone, C.; Mestre, V. F.; Medeiros-Fonseca, B.; Colaço, B.; Pires, M. J.; Martins, T.; Gil da Costa, R. M.; Neuparth, M. J.; Medeiros, R.; Bastos, M. M. S. M.; Marques-Magallanes, J. A.; Oliveira, P. A. (2018) Ozone therapy prevents the onset of dysplasia in HPV16-transgenic mice-A pre-clinical efficacy and safety analysis. Biomedicine & Pharmacotherapy 104 :275-279. doi: 10.1016/j.biopha.2018.05.018. (Impact factor, Quartile: 3.457, Q2).

Potential effects of sulforaphane to fight obesity.

Martins, Tânia; Colaço, Bruno; Venâncio, Carlos; Pires, Maria J.; Oliveira, Paula A.; Rosa, Eduardo; Antunes, Luis M. (2018) Potential effects of sulforaphane to fight obesity. Journal Of The Science Of Food And Agriculture 98 (8) :2837-2844. doi: 10.1002/jsfa.8898. (Impact factor, Quartile: 2.379, Q1).

Reference Intervals for haematological parameters in the Lusitano horse breed.

Silvestre-Ferreira, Ana Cristina; Cotovio, Mário; Maia, Mário; Queiroga, Felisbina, Pires, M.João; Colaço, Ana. (2018) Reference Intervals for haematological parameters in the Lusitano horse breed. ACTA VETERINARIA HUNGARICA 66 (4) :530-541. doi: 10.1556/004.2018.047. (Impact factor, Quartile: 1.042, Q2).

A Contrast Enhanced Ultrasonographic Study About the Impact of Long term Exercise Training on Mammary Tumor Vascularization.

Faustino Rocha, AIF, Gama, A, Oliveira, PA, Vanderperren, K, Saunders, JH, Pires, MJ, Ferreira, R, Ginja, M (2017) A Contrast Enhanced Ultrasonographic Study About the Impact of Long term Exercise Training on Mammary Tumor Vascularization. Journal Of Ultrasound In Medicine 36 :2459-2466. ISSN: 0278-4297. doi: 10.1002/jum.14287. (Impact factor, Quartile: 1.547, Q3).

HPV16 induces a wasting syndrome in transgenic mice: Amelioration by dietary polyphenols via NF-kappa B inhibition.

da Costa, RMG, Aragao, S, Moutinho, M, Alvarado, A, Carmo, D, Casaca, F, Silva, S, Ribeiro, J, Sousa, H, Ferreira, R, Nogueira-Ferreira, R, Pires, MJ, Colaço, B, Medeiros, R, Venancio, C, Oliveira, MM, Bastos, MMSM, Lopes, C, Oliveira, PA (2017) HPV16 induces a wasting syndrome in transgenic mice: Amelioration by dietary polyphenols via NF-kappa B inhibition. Life Sciences 169 :19-Nov. ISSN: 0024-3205. doi: 10.1016/j.lfs.2016.10.031. (Impact factor, Quartile: 2.963, Q2).

Modulation of mammary tumor vascularization by mast cells: Ultrasonographic and histopathological approaches.

Faustino-Rocha, AI, Gama, A, Oliveira, PA, Katrien, VE, Saunders, JH, Pires, MJ, Ferreira, R, Ginja, M (2017) Modulation of mammary tumor vascularization by mast cells: Ultrasonographic and histopathological approaches. Life Sciences 176 :35-41. ISSN: 0024-3205. doi: 10.1016/j.lfs.2017.03.013. (Impact factor, Quartile: 2.963, Q2).

Maria João Miranda Pires Integrated Member

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