Amélia Maria Lopes Dias da Silva Full Member

BIO

Name: Amélia Maria Lopes Dias da Silva

Aggregation: Full Member

Orcid ID: 0000-0002-7524-9914

Email: amsilva@utad.pt

URL:

Phone:

Publications

Chemical Characterization and Bioactivity of Extracts from Thymus mastichina: A Thymus with a Distinct Salvianolic Acid Composition.
Taghouti, Meriem; Martins-Gomes, Carlos; Schafer, Judith; Santos, João A.; Bunzel, Mirko; Nunes, Fernando M.; Silva, Amélia M. (2020) Chemical Characterization and Bioactivity of Extracts from Thymus mastichina: A Thymus with a Distinct Salvianolic Acid Composition. ANTIOXIDANTS 9 :34. doi: 10.3390/antiox9010034. (Impact factor, Quartile: 4.520, Q1).

Effect of harvesting year and elderberry cultivar on the chemical composition and potential bioactivity: a three-year study.
Ferreira, Sandrine S.; Silva, Pedro; Silva, Amélia M.; Nunes, Fernando M. (2020) Effect of harvesting year and elderberry cultivar on the chemical composition and potential bioactivity: a three-year study. FOOD CHEMISTRY 302 :125366. doi: 10.1016/j.foodchem.2019.125366. (Impact factor, Quartile: 5.399, Q1).

3D Printing in the Design of Pharmaceutical Dosage Forms.
Souto, E.B.; Campos, J.R.; Filho, S.C.; Teixeira, M.C.; Martins-Gomes, C.; Zielinska, A.; Carbone, C.; Silva, A.M. (2019) 3D Printing in the Design of Pharmaceutical Dosage Forms. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY 24 (8) :1044-1053. doi: 10.1080/10837450.2019.1630426. (Impact factor, Quartile: 2.347, Q2).

Clotrimazole-loaded Mediterranean Essential Oils NLC: a synergic treatment of Candida Skin Infections.
Carbone, Claudia; Teixeira, Maria do Céu; Sousa, Maria do Céu; Martins-Gomes, Carlos; Silva, Amélia M.; Souto, Eliana B.; Musumeci, Teresa (2019) Clotrimazole-loaded Mediterranean Essential Oils NLC: a synergic treatment of Candida Skin Infections. PHARMACEUTICS 11 (5) :231. doi: 10.3390/pharmaceutics11050231. (Impact factor, Quartile: 4.773, Q1).

Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines.
Silva, Amélia M.; Martins-Gomes, Carlos; Fangueiro, Joana F.; Andreani, Tatiana; Souto, Eliana B. (2019) Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY 24 (10) :1243-1249. doi: 10.1080/10837450.2019.1658774. (Impact factor, Quartile: 2.347, Q2).

Ginkgo biloba L. Leaf Extract Protects HepG2 Cells Against Paraquat-Induced Oxidative DNA Damage.
Silva, Amélia M.; Silva, Sandra C.; Soares, Jorge P., Martins-Gomes, Carlos; Teixeira, João P.; Leal, Fernanda; Gaivão, Isabel (2019) Ginkgo biloba L. Leaf Extract Protects HepG2 Cells Against Paraquat-Induced Oxidative DNA Damage. PLANTS 8 (12) :556. doi: 10.3390/plants8120556. (Impact factor, Quartile: 2.632, Q1).

In vitro cytotoxicity of oleanolic/ursolic acids-loaded in PLGA nanoparticles in different cell lines.
Silva, Amélia M.; Alvarado, Helen L.; Abrego, Gaudalupe; Martins-Gomes, Carlos; Garduño-Ramirez, Maria L.; García, Maria L.; Calpena, Ana C.; Souto, Eliana B. (2019) In vitro cytotoxicity of oleanolic/ursolic acids-loaded in PLGA nanoparticles in different cell lines. PHARMACEUTICS 11 (8) :362. doi: 10.3390/pharmaceutics11080362. (Impact factor, Quartile: 4.773, Q1).

Myasthenia Gravis: State of the art and new therapeutic strategies.
Souto, Eliana B.; Lima, Bernardo; Campos, Joana; Martins Gomes, Carlos; Souto, Selma B.; Silva, Amelia M. (2019) Myasthenia Gravis: State of the art and new therapeutic strategies. JOURNAL OF NEUROIMMUNOLOGY 337 :577080. doi: 10.1016/j.jneuroim.2019.577080. (Impact factor, Quartile: 2.832, Q2).

Photophysicochemical properties and in iitro phototherapeutic effects of iodoquinoline- and benzothiazole-derived unsymmetrical squaraine cyanine dyes.
Friães, Sofia; Lima, Eurico; Boto, Renato E.; Ferreira, Diana; Fernandes, José R.; Ferreira, Luis F.V.; Silva, Amélia M.; Reis, Lucinda V. (2019) Photophysicochemical properties and in iitro phototherapeutic effects of iodoquinoline- and benzothiazole-derived unsymmetrical squaraine cyanine dyes. APPLIED SCIENCES 9 (24) :5414. doi: 10.3390/app9245414. (Impact factor, Quartile: 2.270, Q1).

Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome – review on classical and new compounds: part-I.
Vieira, Raquel; Souto, Selma B.; Sánchez-López, Elena; Machado, Ana L.; Severino, Patricia; Jose, Sajan; Santini, Antonello; Fortuna, Ana; García, Maria Luisa; Silva, Amelia M.; Souto, Eliana B. (2019) Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome – review on classical and new compounds: part-I. PHARMACEUTICALS 12 :152. doi: 10.3390/ph12040152. (Impact factor, Quartile: 4.773, Q1).

Surface-tailored anti-HER2/neu-solid lipid nanoparticles for site-specific targeting MCF-7 and BT-474 breast cancer cells.
Souto, Eliana B.; Doktorovova, Slavomira; Campos, Joana R.; Martins-Lopes, Paula; Silva, Amélia M. (2019) Surface-tailored anti-HER2/neu-solid lipid nanoparticles for site-specific targeting MCF-7 and BT-474 breast cancer cells. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 128 :27-35. doi: 10.1016/j.ejps.2018.11.022. (Impact factor, Quartile: 3.532, Q1).

The influence of polysaccharide coating on the physicochemical parameters and cytotoxicity of silica nanoparticles for hydrophilic biomolecules delivery.
Andreani, Tatiana; Fangueiro, Joana F.; Severino, Patrícia; Souza, Ana L.; Martins-Gomes, Carlos; Fernandes, Paulo M.; Calpena, Ana C.; Gremião, Maria P.; Souto, Eliana B.; Silva, Amélia M. (2019) The influence of polysaccharide coating on the physicochemical parameters and cytotoxicity of silica nanoparticles for hydrophilic biomolecules delivery. NANOMATERIALS 9 (8) :1081. doi: 10.3390/nano9081081. (Impact factor, Quartile: 4.034, Q1).

Thymus carnosus extracts induce anti-proliferative activity in Caco-2 cells through mechanisms that involve cell cycle arrest and apoptosis.
Martins-Gomes, Carlos; Souto, Eliana B.; Cosme, Fernanda; Nunes, Fernando M.; Silva, Amélia M. (2019) Thymus carnosus extracts induce anti-proliferative activity in Caco-2 cells through mechanisms that involve cell cycle arrest and apoptosis. JOURNAL OF FUNCTIONAL FOODS 54 :128-135. doi: 10.1016/j.jff.2019.01.010. (Impact factor, Quartile: 3.197, Q1).

Trends in Atopic Dermatitis - from standard pharmacotherapy to novel drug delivery systems.
Souto, Eliana B.; Dias-Ferreira, João; Oliveira, Jessica; Sanchez-Lopez, Elena; Lopez-Machado, Ana; Espina, Marta; Garcia, Maria Luisa; Souto, Selma B.; Martins-Gomes, Carlos; Silva, Amélia M. (2019) Trends in Atopic Dermatitis - from standard pharmacotherapy to novel drug delivery systems. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20 (22) :5659. doi: 10.3390/ijms20225659. (Impact factor, Quartile: 4.183, Q1).

Uveal melanoma: physiopathology and new in situ-specific therapies.
Souto, E.B.; Zielinska, A.; Luis, M.; Carbone, C.; Martins-Gomes, C.; Souto, S.B.; Silva, A.M. (2019) Uveal melanoma: physiopathology and new in situ-specific therapies. CANCER CHEMOTHERAPY AND PHARMACOLOGY 84 (1) :15-32. doi: 10.1007/s00280-019-03860-z. (Impact factor, Quartile: 3.008, Q1).

Anti-inflammatory and Anti-cancer Activity of Citral: Optimization of Citral-loaded Solid Lipid Nanoparticles (SLN) using Experimental Factorial Design and LUMiSizer.
Zielińska, Alexandra; Martins-Gomes, Carlos; Ferreira, Nuno R. ; Silva, Amélia M.; Nowak, I.; Souto, Eliana B. (2018) Anti-inflammatory and Anti-cancer Activity of Citral: Optimization of Citral-loaded Solid Lipid Nanoparticles (SLN) using Experimental Factorial Design and LUMiSizer. INTERNATIONAL JOURNAL OF PHARMACEUTICS 553 (2-Jan) :428-440. doi: 10.1016/j.ijpharm.2018.10.065. (Impact factor, Quartile: 3.862, Q1).

Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss.
Martins-Gomes, Carlos; Taghouti, Meriem; Schaefer, Judith; Bunzel, Mirko; Silva, Amelia M.; Nunes, Fernando M. (2018) Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss. Journal Of Functional Foods 43 :154-164. doi: 10.1016/j.jff.2018.02.012. (Impact factor, Quartile: 3.47, Q1).

Citrus reticulata Blanco peels as a source of antioxidant and anti-proliferative phenolic compounds.
Ferreira, Sandrine S.; Silva, Amelia M.; Nunes, Fernando M. (2018) Citrus reticulata Blanco peels as a source of antioxidant and anti-proliferative phenolic compounds. Industrial Crops And Products 111 :141-148. doi: 10.1016/j.indcrop.2017.10.009. (Impact factor, Quartile: 3.849, Q1).

Hansen solubility parameters (HSP) for prescreening formulation of solid lipid nanoparticles (SLN): in vitro testing of curcumin-loaded SLN in MCF-7 and BT-474 cell lines.
Doktorovova, Slavomira; Souto, Eliana B.; Silva, Amelia M. (2018) Hansen solubility parameters (HSP) for prescreening formulation of solid lipid nanoparticles (SLN): in vitro testing of curcumin-loaded SLN in MCF-7 and BT-474 cell lines. Pharmaceutical Development And Technology 23 (1) :96-105. doi: 10.1080/10837450.2017.1384491. (Impact factor, Quartile: 1.945, Q3).

Linalool Bioactive Properties and Potential Applicability in Drug Delivery Systems.
Pereira, I.; Severino, Patrícia; Santos, Ana C.; Silva, Amélia M.; Souto, Eliana B. (2018) Linalool Bioactive Properties and Potential Applicability in Drug Delivery Systems. Colloids And Surfaces B-Biointerfaces 171 :566-578. doi: 10.1016/j.colsurfb.2018.08.001. (Impact factor, Quartile: 3.997, Q1).

Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles.
Carbone, C.; Martins-Gomes, C.; Caddeo, C.; Silva, A. M.; Musumeci, T.; Pignatello, R.; Puglisi, G.; Souto, E. B. (2018) Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles. International Journal Of Pharmaceutics 548 (1) :217-226. doi: 10.1016/j.ijpharm.2018.06.064. (Impact factor, Quartile: 3.862, Q1).

Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization.
Sanchez-Lopez, Elena; Ettcheto, Miren; Antonia Egea, Maria; Espina, Marta; Cano, Amanda; Cristina Calpena, Ana; Camins, Antoni; Carmona, Nuria; Silva, Amelia M.; Souto, Eliana B.; Luisa Garcia, Maria (2018) Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization. Journal Of Nanobiotechnology 16. doi: 10.1186/s12951-018-0356-z. (Impact factor, Quartile: 5.294, Q1).

Memantine-Loaded PEGylated Biodegradable Nanoparticles for the Treatment of Glaucoma.
Sanchez-Lopez, Elena; Antonia Egea, Maria; Davis, Benjamin Michael; Guo, Li; Espina, Marta; Silva, Amelia Maria; Cristina Calpena, Ana; Barbosa Souto, Eliana Maria; Ravindran, Nivedita; Ettcheto, Miren; Camins, Antonio; Luisa Garcia, Maria; Cordeiro, Maria Francesca (2018) Memantine-Loaded PEGylated Biodegradable Nanoparticles for the Treatment of Glaucoma. Small 14 (2). doi: 10.1002/smll.201701808. (Impact factor, Quartile: 9.598, Q1).

Optimization of Linalool-loaded Solid Lipid Nanoparticles using Experimental Factorial Design and Long-term Stability Studies with a New Centrifugal Sedimentation Method.
Pereira, I.; Alexandra Zielińska; Nuno R. Ferreira; Amélia M. Silva; Eliana B. Souto (2018) Optimization of Linalool-loaded Solid Lipid Nanoparticles using Experimental Factorial Design and Long-term Stability Studies with a New Centrifugal Sedimentation Method. International Journal Of Pharmaceutics 549 (1) :261-270. doi: 10.1016/j.ijpharm.2018.07.068. (Impact factor, Quartile: 3.862, Q1).

Optimization, Biopharmaceutical Profile and Therapeutic Efficacy of Pioglitazone-loaded PLGA-PEG Nanospheres as a Novel Strategy for Ocular Inflammatory Disorders.
Silva-Abreu, Marcelle; Cristina Calpena, Ana; Espina, Marta; Silva, Amelia M.; Gimeno, Alvaro; Antonia Egea, Maria; Luisa Garcia, Maria (2018) Optimization, Biopharmaceutical Profile and Therapeutic Efficacy of Pioglitazone-loaded PLGA-PEG Nanospheres as a Novel Strategy for Ocular Inflammatory Disorders. Pharmaceutical Research 35 (1). doi: 10.1007/s11095-017-2319-8. (Impact factor, Quartile: 3.335, Q2).

Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy.
Carbone, C.; Martins-Gomes, C.; Pepe, V.; Silva, A. M.; Musumeci, T.; Puglisi, G.; Furneri, P. M.; Souto, E. B. (2018) Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy. Colloids And Surfaces B-Biointerfaces 167 :337-344. doi: 10.1016/j.colsurfb.2018.04.031. (Impact factor, Quartile: 3.997, Q1).

Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds.
Taghouti, Meriem; Martins-Gomes, Carlos; Schaefer, Judith; Felix, Luis M.; Santos, Joao A.; Bunzel, Mirko; Nunes, Fernando M.; Silva, Amelia M. (2018) Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds. Food & Function 9 (7) :3617-3629. doi: 10.1039/c8fo00456k. (Impact factor, Quartile: 3.289, Q1).

Titanium dioxide nanoparticles: Toxicity and genotoxicity in Drosophila melanogaster (SMART eye-spot test and comet assay in neuroblasts).
Sario, Sara; Silva, Amelia M.; Gaivao, Isabel (2018) Titanium dioxide nanoparticles: Toxicity and genotoxicity in Drosophila melanogaster (SMART eye-spot test and comet assay in neuroblasts). Mutation Research-Genetic Toxicology And Environmental Mutagenesis 831 :19-23. doi: 10.1016/j.mrgentox.2018.05.001. (Impact factor, Quartile: 1.996, Q3).

Influence of the stabilizers on the toxicity of metallic nanomaterials in aquatic organisms and human cell lines.
Andreani, T, Nogueira, V, Pinto, VV, Ferreira, MJ, Rasteiro, MG, Silva, AM, Pereira, R, Pereira, CM (2017) Influence of the stabilizers on the toxicity of metallic nanomaterials in aquatic organisms and human cell lines. Science Of The Total Environment 607 :1264-1277. ISSN: 0048-9697. doi: 10.1016/j.scitotenv.2017.07.098. (Impact factor, Quartile: 4.9, Q1).

Soft Cationic Nanoparticles for Drug Delivery: Production and Cytotoxicity of Solid Lipid Nanoparticles (SLN).
Silva, Amélia M.; Martins-Gomes, Carlos; Coutinho, Tiago E.; Fangueiro, Joana F.; Sanchez-Lopez, E.; Pashirova, Tatiana N.; Souto, Eliana B. Soft Cationic Nanoparticles for Drug Delivery: Production and Cytotoxicity of Solid Lipid Nanoparticles (SLN). APPLIED SCIENCES 9 (20) :4438. doi: 10.3390/app9204438. (Impact factor, Quartile: 2.217, Q1).

Projects

FungiTech - Technology and innovation in the production chain of shiitake and other mushrooms with nutraceutical value and medicine
Running

UTAD/CITAB Coordinator  /  Guilhermina Marques
Start date  /  2018/07 Funding  /  Norte2020


Safe NPest: Synthesis and Environmental Safety of Nanopesticides
Running

Coordinator  /  Tatiana Andreani UTAD/CITAB Coordinator  /  Amélia Silva
Start date  /  2018/07 Funding  /  FCT/FEDER


PAIRED - Magnetically and photochemically actuated bioactive nanowires for remotely controlled drug delivery
Running

UTAD/CITAB Coordinator  /  Amélia Silva
Start date  /  2016/10 Funding  /  European Commission - ERA-NETS


INTERACT - Integrative Research in Environment, Agro-Chains and Technology
Running

Coordinator  /  Rui Cortes
Start date  /  2016/05 Funding  /  NORTE2020


IBERPHENOL- Research cooperation network in polyphenols and its industrial applications”
Running

Coordinator  /  Julián Rivas Gonzal UTAD/CITAB Coordinator  /  Eduardo Rosa
Start date  /  2015/10 Funding  /  INTERREG - POCTEP (Spain - Portugal)


INNOFOOD - INNOVation in the FOOD sector through the valorization of food and agro-food by-products
Concluded

Coordinator  /  Ana Barros
Start date  /  2014/01


MELHORA DAS PROPRIEDADES DE SAUDE DOS ALIMENTOS, COMPARTILHANDO O CONHECIMENTO SOBRE O PROCESSO DIGESTIVO (INFOGEST)
Concluded

Coordinator  /  Didier Dupont UTAD/CITAB Coordinator  /  Raul Perles
Start date  /  2013/05 Funding  /  European Cooperation in Science and Technology (COST)


NanoSKIN: Nanopartículas contendo agentes quimioterapêuticos para terapias inovadoras de doenças severas da pele – Leishmaniase muco/cutânea e carcinoma espinocelular como exemplos.
Concluded

Coordinator  /  Eliana B Souto (UFP-Porto; CGB-UTAD) UTAD/CITAB Coordinator  /  Amélia Silva
Start date  /  2011/05


PromoAgro - Promoção da Competitividade Agro-alimentar
Concluded

Coordinator  /  Eduardo Rosa
Start date  /  2010/10 Funding  /  CCDRN - ON.2


NutriDouro: Frutas confitadas e compotas saudáveis, o sabor tradicional
Concluded

Coordinator  /  Dr. Pilar Santos (Douromel) Start date  /  2010/06 Funding  /  QREN-Copromoção