Amélia Maria Lopes Dias da Silva Integrated Member

CV Ciência Vitae

BIO

Name: Amélia Maria Lopes Dias da Silva

Aggregation: Integrated Member

Scopus author ID: 35578752300

Orcid ID: 0000-0002-7524-9914

Ciência Vitae: 241E-3956-0242

Email: amsilva@utad.pt

Research Tasks

Innovative technologies and processes

Valorisation of bio-based products and and co-products

Publications

From cultural and natural heritage to reservoir of biomedicine: Prospection of bioactive compounds produced by bacterial isolates from caves

Gatinho P., Salvador C., Gutierrez-Patricio S., Macedo-Arantes S., Martins M.R., Silva A.M., Miller A.Z., Caldeira A.T., (2024) From cultural and natural heritage to reservoir of biomedicine: Prospection of bioactive compounds produced by bacterial isolates from caves International Biodeterioration and Biodegradation 190 (105773). doi: 10.1016/j.ibiod.2024.105773.

Hibiscus sabdariffa-loaded nanostructured lipid carriers (NLC) for fortified nutraceutical milks

Pimentel-Moral S., Durazzo A., Lucarini M., Fernández-Ochoa Á., de la Luz Cádiz-Gurrea M., Arráez-Román D., Silva A.M., Santini A., Fonseca J., Segura-Carretero A., Souto E.B., (2024) Hibiscus sabdariffa-loaded nanostructured lipid carriers (NLC) for fortified nutraceutical milks European Food Research and Technology 250 :1999-2010. ISSN: 14382385. doi: 10.1007/s00217-024-04509-9.

Labdanum Resin from Cistus ladanifer L. as a Source of Compounds with Anti-Diabetic, Neuroprotective and Anti-Proliferative Activity

Frazão D.F., Martins-Gomes C., Díaz T.S., Delgado F., Gonçalves J.C., Silva A.M., (2024) Labdanum Resin from Cistus ladanifer L. as a Source of Compounds with Anti-Diabetic, Neuroprotective and Anti-Proliferative Activity Molecules 29 (2222). ISSN: 14203049. doi: 10.3390/molecules29102222.

Linking Variability in Phytochemical Composition with Safety Profile of Thymus carnosus Boiss. Extracts: Effect of Major Compounds and Evaluation of Markers of Oxidative Stress and Cell Death

Martins-Gomes C., Nunes F.M., Silva A.M., (2024) Linking Variability in Phytochemical Composition with Safety Profile of Thymus carnosus Boiss. Extracts: Effect of Major Compounds and Evaluation of Markers of Oxidative Stress and Cell Death International Journal of Molecular Sciences 25 (5343). ISSN: 14220067. doi: 10.3390/ijms25105343.

Thymus spp. Aqueous Extracts and Their Constituent Salvianolic Acid A Induce Nrf2-Dependent Cellular Antioxidant Protection Against Oxidative Stress in Caco-2 Cells

Martins-Gomes C., Nunes F.M., Silva A.M., (2024) Thymus spp. Aqueous Extracts and Their Constituent Salvianolic Acid A Induce Nrf2-Dependent Cellular Antioxidant Protection Against Oxidative Stress in Caco-2 Cells Antioxidants 13 (1287). ISSN: 20763921. doi: 10.3390/antiox13111287.

Biopharmaceutical applications of Opuntia ficus-indica: bibliometric map, bioactivities and extraction techniques

Guedes B.N., Fathi F., Silva A.M., Santini A., Oliveira M.B.P.P., Souto E.B., (2023) Biopharmaceutical applications of Opuntia ficus-indica: bibliometric map, bioactivities and extraction techniques European Food Research and Technology 249 :2457-2469. ISSN: 14382385. doi: 10.1007/s00217-023-04314-w.

Cell penetrating peptides-functionalized Licochalcone-A-loaded PLGA nanoparticles for ocular inflammatory diseases: Evaluation of in vitro anti-proliferative effects, stabilization by freeze-drying and characterization of an in-situ forming gel

Galindo-Camacho R.M., Haro I., Gómara M.J., Espina M., Fonseca J., Martins-Gomes C., Camins A., Silva A.M., García M.L., Souto E.B., (2023) Cell penetrating peptides-functionalized Licochalcone-A-loaded PLGA nanoparticles for ocular inflammatory diseases: Evaluation of in vitro anti-proliferative effects, stabilization by freeze-drying and characterization of an in-situ forming gel International Journal of Pharmaceutics 639 (122982). ISSN: 18733476. doi: 10.1016/j.ijpharm.2023.122982.

Effect of cultivar, maturation stage, and year on sugar and phenolic composition of elderberries

Ferreira S.S., Silva P., Silva A.M., Nunes F.M., (2023) Effect of cultivar, maturation stage, and year on sugar and phenolic composition of elderberries Journal of the Science of Food and Agriculture 103 :2023-2036. ISSN: 10970010. doi: 10.1002/jsfa.12271.

Modified Drug Delivery Systems for Veterinary Use: Pharmaceutical Development and Applications

Souto E.B., Barbosa C.I., Baldim I., Campos J.R., Fernandes A.R., Mazzola P.G., Andreani T., Dias I.R., Durazzo A., Lucarini M., Atanasov A.G., Silva A.M., Santini A., (2023) Modified Drug Delivery Systems for Veterinary Use: Pharmaceutical Development and Applications Current Bioactive Compounds 19 (e040422203061) :69-76. ISSN: 18756646. doi: 10.2174/1573407218666220404110837.

Modulation of Cell Death Pathways for Cellular Protection and Anti-Tumoral Activity: The Role of Thymus spp. Extracts and Their Bioactive Molecules

Martins-Gomes C., Nunes F.M., Silva A.M., (2023) Modulation of Cell Death Pathways for Cellular Protection and Anti-Tumoral Activity: The Role of Thymus spp. Extracts and Their Bioactive Molecules International Journal of Molecular Sciences 24 (1691). ISSN: 14220067. doi: 10.3390/ijms24021691.

Molecular Characterization of Prunus lusitanica L. Fruit Extracts and Their Health-Promoting Potential in Inflammation, Diabetes, and Neurodegenerative Diseases

Abraão A., Martins-Gomes C., Domínguez-Perles R., Barros A., Silva A.M., (2023) Molecular Characterization of Prunus lusitanica L. Fruit Extracts and Their Health-Promoting Potential in Inflammation, Diabetes, and Neurodegenerative Diseases International Journal of Molecular Sciences 24 (8830). ISSN: 14220067. doi: 10.3390/ijms24108830.

Natural Products as a Tool to Modulate the Activity and Expression of Multidrug Resistance Proteins of Intestinal Barrier

Martins-Gomes C., Silva A.M., (2023) Natural Products as a Tool to Modulate the Activity and Expression of Multidrug Resistance Proteins of Intestinal Barrier Journal of Xenobiotics 13 :172-192. ISSN: 20394713. doi: 10.3390/jox13020014.

Phytochemical Composition and Antioxidant, Anti-Acetylcholinesterase, and Anti-α-Glucosidase Activity of Thymus carnosus Extracts: A Three-Year Study on the Impact of Annual Variation and Geographic Location

Martins-Gomes C., Steck J., Keller J., Bunzel M., Santos J.A., Nunes F.M., Silva A.M., (2023) Phytochemical Composition and Antioxidant, Anti-Acetylcholinesterase, and Anti-α-Glucosidase Activity of Thymus carnosus Extracts: A Three-Year Study on the Impact of Annual Variation and Geographic Location Antioxidants 12 (668). ISSN: 20763921. doi: 10.3390/antiox12030668.

Prokaryotic Communities from Pristine Cave Environments: Biotechnological Potential with Sustainable Production

Gatinho P., Salvador C., Silva A.M., Caldeira A.T., (2023) Prokaryotic Communities from Pristine Cave Environments: Biotechnological Potential with Sustainable Production Sustainability (Switzerland) 15 (7471). ISSN: 20711050. doi: 10.3390/su15097471.

Prunus lusitanica L. Fruits: A Promising Underexploited Source of Nutrients with Potential Economic Value

Abraão A., Yu M., Gouvinhas I., Ferreira L., Silva A.M., Domínguez-Perles R., Barros A., (2023) Prunus lusitanica L. Fruits: A Promising Underexploited Source of Nutrients with Potential Economic Value Foods 12 (973). ISSN: 23048158. doi: 10.3390/foods12050973.

Rockrose Land Management: Contribution of Periodic Harvesting to Increase Value and to Control Cistus ladanifer L. Shrublands

Frazão D.F., Gonçalves J.C., Silva A.M., Delgado F., (2023) Rockrose Land Management: Contribution of Periodic Harvesting to Increase Value and to Control Cistus ladanifer L. Shrublands Forests 14 (638). ISSN: 19994907. doi: 10.3390/f14030638.

Applications of nanotechnology in chronic diseases and tissue regeneration

Formoso I., Shegokar R., Zielinska A., Silva A.M., Souto E.B., (2022) Applications of nanotechnology in chronic diseases and tissue regeneration Nanotechnology and Regenerative Medicine: History, Techniques, Frontiers, and Applications :507-527. doi: 10.1016/B978-0-323-90471-1.00021-9.

Chemical Composition and Potential Biological Activity of Melanoidins From Instant Soluble Coffee and Instant Soluble Barley: A Comparative Study

Antonietti S., Silva A.M., Simões C., Almeida D., Félix L.M., Papetti A., Nunes F.M., (2022) Chemical Composition and Potential Biological Activity of Melanoidins From Instant Soluble Coffee and Instant Soluble Barley: A Comparative Study Frontiers in Nutrition 9 (825584). ISSN: 2296861X. doi: 10.3389/fnut.2022.825584.

Customized cationic nanoemulsions loading triamcinolone acetonide for corneal neovascularization secondary to inflammatory processes

Fernandes A.R., Vidal L.B., Sánchez-López E., dos Santos T., Granja P.L., Silva A.M., Garcia M.L., Souto E.B., (2022) Customized cationic nanoemulsions loading triamcinolone acetonide for corneal neovascularization secondary to inflammatory processes International Journal of Pharmaceutics 623 (121938). ISSN: 18733476. doi: 10.1016/j.ijpharm.2022.121938.

Elderberry (Sambucus nigra L.) extracts promote anti-inflammatory and cellular antioxidant activity

Ferreira S.S., Martins-Gomes C., Nunes F.M., Silva A.M., (2022) Elderberry (Sambucus nigra L.) extracts promote anti-inflammatory and cellular antioxidant activity Food Chemistry: X 15 (100437). ISSN: 25901575. doi: 10.1016/j.fochx.2022.100437.

Exudative versus Nonexudative Age-Related Macular Degeneration: Physiopathology and Treatment Options

Fernandes A.R., Zielińska A., Sanchez-Lopez E., Dos Santos T., Garcia M.L., Silva A.M., Karczewski J., Souto E.B., (2022) Exudative versus Nonexudative Age-Related Macular Degeneration: Physiopathology and Treatment Options International Journal of Molecular Sciences 23 (2592). ISSN: 14220067. doi: 10.3390/ijms23052592.

Glyphosate vs. Glyphosate-Based Herbicides Exposure: A Review on Their Toxicity

Martins-Gomes C., Silva T.L., Andreani T., Silva A.M., (2022) Glyphosate vs. Glyphosate-Based Herbicides Exposure: A Review on Their Toxicity Journal of Xenobiotics 12 :21-40. ISSN: 20394713. doi: 10.3390/jox12010003.

Hydrogels for Modified-release Drug Delivery Systems

Zielińska A., Eder P., Rannier L., Cardoso J.C., Severino P., Silva A.M., Souto E.B., (2022) Hydrogels for Modified-release Drug Delivery Systems Current Pharmaceutical Design 28 :609-618. ISSN: 18734286. doi: 10.2174/1381612828666211230114755.

In Vitro Assessment of Pesticides Toxicity and Data Correlation with Pesticides Physicochemical Properties for Prediction of Toxicity in Gastrointestinal and Skin Contact Exposure

Silva A.M., Martins-Gomes C., Silva T.L., Coutinho T.E., Souto E.B., Andreani T., (2022) In Vitro Assessment of Pesticides Toxicity and Data Correlation with Pesticides Physicochemical Properties for Prediction of Toxicity in Gastrointestinal and Skin Contact Exposure Toxics 10 (378). ISSN: 23056304. doi: 10.3390/toxics10070378.

Labdanum Resin from Cistus ladanifer L.: A Natural and Sustainable Ingredient for Skin Care Cosmetics with Relevant Cosmeceutical Bioactivities

Frazão D.F., Martins-Gomes C., Steck J.L., Keller J., Delgado F., Gonçalves J.C., Bunzel M., Pintado C.M.B.S., Díaz T.S., Silva A.M., (2022) Labdanum Resin from Cistus ladanifer L.: A Natural and Sustainable Ingredient for Skin Care Cosmetics with Relevant Cosmeceutical Bioactivities Plants 11 (1477). ISSN: 22237747. doi: 10.3390/plants11111477.

Lipid nanoparticles-based semisolid formulations for cosmetic applications: focus on cellulite

Silva A.M., Cruz A.T., Nobre J., Coutinho T.E., Cano A., Zielinska A., Kovačević A., Severino P., Souto E.B., (2022) Lipid nanoparticles-based semisolid formulations for cosmetic applications: focus on cellulite Nanotechnology and Regenerative Medicine: History, Techniques, Frontiers, and Applications :179-193. doi: 10.1016/B978-0-323-90471-1.00014-1.

Lipid-Based Nanoparticulate Systems for the Ocular Delivery of Bioactives with Anti-Inflammatory Properties

Ana R.d., Fonseca J., Karczewski J., Silva A.M., Zielińska A., Souto E.B., (2022) Lipid-Based Nanoparticulate Systems for the Ocular Delivery of Bioactives with Anti-Inflammatory Properties International Journal of Molecular Sciences 23 (12102). ISSN: 14220067. doi: 10.3390/ijms232012102.

Lipid-Drug Conjugates and Nanoparticles for the Cutaneous Delivery of Cannabidiol

Zielińska A., Cano A., Andreani T., Martins-Gomes C., Silva A.M., Szalata M., Słomski R., Souto E.B., (2022) Lipid-Drug Conjugates and Nanoparticles for the Cutaneous Delivery of Cannabidiol International Journal of Molecular Sciences 23 (6165). ISSN: 14220067. doi: 10.3390/ijms23116165.

Major anthocyanins in elderberry effectively trap methylglyoxal and reduce cytotoxicity of methylglyoxal in HepG2 cell line

Ferreira S.S., Domingues M.R., Barros C., Santos S.A.O., Silvestre A.J.D., Silva A.M., Nunes F.M., (2022) Major anthocyanins in elderberry effectively trap methylglyoxal and reduce cytotoxicity of methylglyoxal in HepG2 cell line Food Chemistry: X 16 (100468). ISSN: 25901575. doi: 10.1016/j.fochx.2022.100468.

Microemulsions and Nanoemulsions in Skin Drug Delivery

Souto E.B., Cano A., Martins-Gomes C., Coutinho T.E., Zielińska A., Silva A.M., (2022) Microemulsions and Nanoemulsions in Skin Drug Delivery Bioengineering 9 (158). ISSN: 23065354. doi: 10.3390/bioengineering9040158.

Molecular Characterization of Thymus capitellatus Extracts and Their Antioxidant, Neuroprotective and Anti-Proliferative Activities

Martins-Gomes C., Steck J., Keller J., Bunzel M., Nunes F.M., Silva A.M., (2022) Molecular Characterization of Thymus capitellatus Extracts and Their Antioxidant, Neuroprotective and Anti-Proliferative Activities International Journal of Molecular Sciences 23 (15187). ISSN: 14220067. doi: 10.3390/ijms232315187.

Molecular Physicochemical Properties of Selected Pesticides as Predictive Factors for Oxidative Stress and Apoptosis-Dependent Cell Death in Caco-2 and HepG2 Cells

Silva A.M., Martins-Gomes C., Ferreira S.S., Souto E.B., Andreani T., (2022) Molecular Physicochemical Properties of Selected Pesticides as Predictive Factors for Oxidative Stress and Apoptosis-Dependent Cell Death in Caco-2 and HepG2 Cells International Journal of Molecular Sciences 23 (8107). ISSN: 14220067. doi: 10.3390/ijms23158107.

Nanophytosomes: a novel approach for the delivery of herbal drugs

Martins-Gomes C., Souto E.B., Silva A.M., (2022) Nanophytosomes: a novel approach for the delivery of herbal drugs Systems of Nanovesicular Drug Delivery :239-257. doi: 10.1016/B978-0-323-91864-0.00015-2.

Nanotechnologies to deliver drugs through the blood–brain and blood–retinal barriers

Costa M.C., Shegokar R., Silva A.M., Souto E.B., (2022) Nanotechnologies to deliver drugs through the blood–brain and blood–retinal barriers Nanotechnology and Regenerative Medicine: History, Techniques, Frontiers, and Applications :45-64. doi: 10.1016/B978-0-323-90471-1.00010-4.

Neurotoxicity Assessment of Four Different Pesticides Using In Vitro Enzymatic Inhibition Assays

Martins-Gomes C., Coutinho T.E., Silva T.L., Andreani T., Silva A.M., (2022) Neurotoxicity Assessment of Four Different Pesticides Using In Vitro Enzymatic Inhibition Assays Toxics 10 (448). ISSN: 23056304. doi: 10.3390/toxics10080448.

Permeability, anti-inflammatory and anti-VEGF profiles of steroidal-loaded cationic nanoemulsions in retinal pigment epithelial cells under oxidative stress

Fernandes A.R., dos Santos T., Granja P.L., Sanchez-Lopez E., Garcia M.L., Silva A.M., Souto E.B., (2022) Permeability, anti-inflammatory and anti-VEGF profiles of steroidal-loaded cationic nanoemulsions in retinal pigment epithelial cells under oxidative stress International Journal of Pharmaceutics 617 (121615). ISSN: 18733476. doi: 10.1016/j.ijpharm.2022.121615.

Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery

Souto E.B., Fangueiro J.F., Fernandes A.R., Cano A., Sanchez-Lopez E., Garcia M.L., Severino P., Paganelli M.O., Chaud M.V., Silva A.M., (2022) Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery Heliyon 8 (e08938). doi: 10.1016/j.heliyon.2022.e08938.

Production Technologies, Regulatory Parameters, and Quality Control of Vaccine Vectors for Veterinary Use

Barbosa R.d.M., Silva A.M., Silva C.F.d., Cardoso J.C., Severino P., Meirelles L.M.A., Silva-Junior A.A.d., Viseras C., Fonseca J., Souto E.B., (2022) Production Technologies, Regulatory Parameters, and Quality Control of Vaccine Vectors for Veterinary Use Technologies 10 (109). ISSN: 22277080. doi: 10.3390/technologies10050109.

Progress of nanotechnology in the development of medicines

Formoso I., Shegokar R., Zielinska A., Eder P., Silva A.M., Souto E.B., (2022) Progress of nanotechnology in the development of medicines Nanotechnology and Regenerative Medicine: History, Techniques, Frontiers, and Applications :1-21. doi: 10.1016/B978-0-323-90471-1.00001-3.

Prunus lusitanica L. Fruits as a Novel Source of Bioactive Compounds with Antioxidant Potential: Exploring the Unknown

Abraão A.S., Fernandes N., Silva A.M., Domínguez-Perles R., Barros A., (2022) Prunus lusitanica L. Fruits as a Novel Source of Bioactive Compounds with Antioxidant Potential: Exploring the Unknown Antioxidants 11 (1738). ISSN: 20763921. doi: 10.3390/antiox11091738.

Selected Flavonoids to Target Melanoma: A Perspective in Nanoengineering Delivery Systems

Coutinho T.E., Souto E.B., Silva A.M., (2022) Selected Flavonoids to Target Melanoma: A Perspective in Nanoengineering Delivery Systems Bioengineering 9 (290). ISSN: 23065354. doi: 10.3390/bioengineering9070290.

Toxicological screening of nanoparticles for biological applications: Drosophila melanogaster as a representative toxicological model

Severino P., Dias-Ferreira J., Andrade L.N., Lima D.M., de Hollanda L.M., da Silva C.F., Chaud M.V., Carbone C., Silva A.M., Lucarini M., Durazzo A., Capasso R., Santini A., Souto E.B., (2022) Toxicological screening of nanoparticles for biological applications: Drosophila melanogaster as a representative toxicological model Nanotechnology and Regenerative Medicine: History, Techniques, Frontiers, and Applications :551-573. doi: 10.1016/B978-0-323-90471-1.00007-4.

Uncaria tomentosa (Willd. ex Schult.): Focus on Nutraceutical Aspects

Nazhand A., Durazzo A., Lucarini M., Silva A.M., Souto S.B., Severino P., Souto E.B., Santini A., (2022) Uncaria tomentosa (Willd. ex Schult.): Focus on Nutraceutical Aspects Current Bioactive Compounds 18 (e021221196131). ISSN: 18756646. doi: 10.2174/1573407217666210903113347.

Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role

Durazzo A., Nazhand A., Lucarini M., Silva A.M., Souto S.B., Guerra F., Severino P., Zaccardelli M., Souto E.B., Santini A., (2021) Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role Rendiconti Lincei 32 :625-642. ISSN: 17200776. doi: 10.1007/s12210-021-01003-2.

Biosurfactants: Properties and applications in drug delivery, biotechnology and ecotoxicology

Bjerk T.R., Severino P., Jain S., Marques C., Silva A.M., Pashirova T., Souto E.B., (2021) Biosurfactants: Properties and applications in drug delivery, biotechnology and ecotoxicology Bioengineering 8 (115). ISSN: 23065354. doi: 10.3390/bioengineering8080115.

Dabco-customized nanoemulsions: Characterization, cell viability and genotoxicity in retinal pigmented epithelium and microglia cells

Fernandes A.R., Dos Santos T., Granja P.L., Sanchez-Lopez E., Santini A., Garcia M.L., Silva A.M., Souto E.B., (2021) Dabco-customized nanoemulsions: Characterization, cell viability and genotoxicity in retinal pigmented epithelium and microglia cells Pharmaceutics 13 (1652). ISSN: 19994923. doi: 10.3390/pharmaceutics13101652.

Development and characterization of nanoemulsions for ophthalmic applications: Role of cationic surfactants

Fernandes A.R., Sanchez-Lopez E., Dos Santos T., Garcia M.L., Silva A.M., Souto E.B., (2021) Development and characterization of nanoemulsions for ophthalmic applications: Role of cationic surfactants Materials 14 (7541). ISSN: 19961944. doi: 10.3390/ma14247541.

Ecotoxicity to freshwater organisms and cytotoxicity of nanomaterials: Are we generating sufficient data for their risk assessment?

Andreani T., Nogueira V., Gavina A., Fernandes S., Rodrigues J.L., Pinto V.V., Ferreira M.J., Silva A.M., Pereira C.M., Pereira R., (2021) Ecotoxicity to freshwater organisms and cytotoxicity of nanomaterials: Are we generating sufficient data for their risk assessment? Nanomaterials 11 (66) :1-25. ISSN: 20794991. doi: 10.3390/nano11010066.

Genotoxicity assessment of metal-based nanocomposites applied in drug delivery

Cardoso S., da Silva C.F., Severino P., Silva A.M., Souto S.B., Zielińska A., Karczewski J., Souto E.B., (2021) Genotoxicity assessment of metal-based nanocomposites applied in drug delivery Materials 14 (6551). ISSN: 19961944. doi: 10.3390/ma14216551.

Mono-and dicationic dabco/quinuclidine composed nanomaterials for the loading of steroidal drug: 3² factorial design and physicochemical characterization

Fernandes A.R., Sanchez-Lopez E., Santini A., Dos Santos T., Garcia M.L., Silva A.M., Souto E.B., (2021) Mono-and dicationic dabco/quinuclidine composed nanomaterials for the loading of steroidal drug: 3² factorial design and physicochemical characterization Nanomaterials 11 (2758). ISSN: 20794991. doi: 10.3390/nano11102758.

Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits

Silva A.M., Félix L.M., Teixeira I., Martins-Gomes C., Schäfer J., Souto E.B., Santos D.J., Bunzel M., Nunes F.M., (2021) Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits Food Chemistry: X 12 (100171). ISSN: 25901575. doi: 10.1016/j.fochx.2021.100171.

Red seaweeds strengthening the nexus between nutrition and health: phytochemical characterization and bioactive properties of Grateloupia turuturu and Porphyra umbilicalis extracts

Ferreira J., Hartmann A., Martins-Gomes C., Nunes F.M., Souto E.B., Santos D.L., Abreu H., Pereira R., Pacheco M., Gaivão I., Silva A.M., (2021) Red seaweeds strengthening the nexus between nutrition and health: phytochemical characterization and bioactive properties of Grateloupia turuturu and Porphyra umbilicalis extracts Journal of Applied Phycology 33 :3365-3381. ISSN: 15735176. doi: 10.1007/s10811-021-02529-6.

(+)-limonene 1,2-epoxide-loaded slns: Evaluation of drug release, antioxidant activity, and cytotoxicity in an HaCaT cell line

Souto E.B., Zielinska A., Souto S.B., Durazzo A., Lucarini M., Santini A., Silva A.M., Atanasov A.G., Marques C., Andrade L.N., Severino P., (2020) (+)-limonene 1,2-epoxide-loaded slns: Evaluation of drug release, antioxidant activity, and cytotoxicity in an HaCaT cell line International Journal of Molecular Sciences 21 (1449). ISSN: 14220067. doi: 10.3390/ijms21041449.

Chemical characterization and bioactivity of extracts from Thymus mastichina: A thymus with a distinct salvianolic acid composition

Taghouti M., Martins-Gomes C., Schäfer J., Santos J.A., Bunzel M., Nunes F.M., Silva A.M., (2020) Chemical characterization and bioactivity of extracts from Thymus mastichina: A thymus with a distinct salvianolic acid composition Antioxidants 9 (34). ISSN: 20763921. doi: 10.3390/antiox9010034.

Diabetic retinopathy and ocular melanoma: How far we are?

Souto E.B., Campos J.R., Da Ana R., Fangueiro J.F., Martins-Gomes C., Durazzo A., Lucarini M., López E.S., Espina M., García M.L., Silva A.M., Mendonça F., Santini A., Souto S.B., (2020) Diabetic retinopathy and ocular melanoma: How far we are? Applied Sciences (Switzerland) 10 (2777). ISSN: 20763417. doi: 10.3390/APP10082777.

Effect of harvesting year and elderberry cultivar on the chemical composition and potential bioactivity: A three-year study

Ferreira S.S., Silva P., Silva A.M., Nunes F.M., (2020) Effect of harvesting year and elderberry cultivar on the chemical composition and potential bioactivity: A three-year study Food Chemistry 302 (125366). ISSN: 18737072. doi: 10.1016/j.foodchem.2019.125366.

Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection

Andreani T., Dias-Ferreira J., Fangueiro J.F., Souza A.L.R., Kiill C.P., Gremião M.P.D., García M.L., Silva A.M., Souto E.B., (2020) Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection Heliyon 6 (e03831). doi: 10.1016/j.heliyon.2020.e03831.

Hawthorn (Crataegus spp.): An updated overview on its beneficial properties

Nazhand A., Lucarini M., Durazzo A., Zaccardelli M., Cristarella S., Souto S.B., Silva A.M., Severino P., Souto E.B., Santini A., (2020) Hawthorn (Crataegus spp.): An updated overview on its beneficial properties Forests 11 (564). ISSN: 19994907. doi: 10.3390/F11050564.

In vitro characterization, modelling, and antioxidant properties of polyphenon-60 from green tea in eudragit s100-2 chitosan microspheres

Souto E.B., da Ana R., Souto S.B., Zielińska A., Marques C., Andrade L.N., Horbańczuk O.K., Atanasov A.G., Lucarini M., Durazzo A., Silva A.M., Novellino E., Santini A., Severino P., (2020) In vitro characterization, modelling, and antioxidant properties of polyphenon-60 from green tea in eudragit s100-2 chitosan microspheres Nutrients 12 (967). ISSN: 20726643. doi: 10.3390/nu12040967.

In vitro phototherapeutic effects of indolenine-based mono- and dithiosquaraine cyanine dyes against Caco-2 and HepG2 human cancer cell lines

Fernandes T.C.D., Lima E., Boto R.E., Ferreira D., Fernandes J.R., Almeida P., Ferreira L.F.V., Silva A.M., Reis L.V., (2020) In vitro phototherapeutic effects of indolenine-based mono- and dithiosquaraine cyanine dyes against Caco-2 and HepG2 human cancer cell lines Photodiagnosis and Photodynamic Therapy 31 (101844). ISSN: 18731597. doi: 10.1016/j.pdpdt.2020.101844.

Lipid nanoparticles as carriers for the treatment of neurodegeneration associated with alzheimer’s disease and glaucoma: Present and future challenges

Lopez E.S., Machado A.L.L., Vidal L.B., Gonzalez-Pizarro R., Silva A.D., Souto E.B., (2020) Lipid nanoparticles as carriers for the treatment of neurodegeneration associated with alzheimer’s disease and glaucoma: Present and future challenges Current Pharmaceutical Design 26 :1235-1250. ISSN: 18734286. doi: 10.2174/1381612826666200218101231.

Metal-based nanoparticles as antimicrobial agents: An overview

Sánchez-López E., Gomes D., Esteruelas G., Bonilla L., Lopez-Machado A.L., Galindo R., Cano A., Espina M., Ettcheto M., Camins A., Silva A.M., Durazzo A., Santini A., Garcia M.L., Souto E.B., (2020) Metal-based nanoparticles as antimicrobial agents: An overview Nanomaterials 10 (292). ISSN: 20794991. doi: 10.3390/nano10020292.

Multiple cell signalling pathways of human proinsulin C-peptide in vasculopathy protection

Souto S.B., Campos J.R., Fangueiro J.F., Silva A.M., Cicero N., Santini A., Souto E.B., (2020) Multiple cell signalling pathways of human proinsulin C-peptide in vasculopathy protection International Journal of Molecular Sciences 21 (645). ISSN: 14220067. doi: 10.3390/ijms21020645.

Nanomaterials for skin delivery of cosmeceuticals and pharmaceuticals

Souto E.B., Fernandes A.R., Martins-Gomes C., Coutinho T.E., Durazzo A., Lucarini M., Souto S.B., Silva A.M., Santini A., (2020) Nanomaterials for skin delivery of cosmeceuticals and pharmaceuticals Applied Sciences (Switzerland) 10 (1594). ISSN: 20763417. doi: 10.3390/app10051594.

Ocular cell lines and genotoxicity assessment

Souto E.B., Campos J.R., Da Ana R., Martins-Gomes C., Silva A.M., Souto S.B., Lucarini M., Durazzo A., Santini A., (2020) Ocular cell lines and genotoxicity assessment International Journal of Environmental Research and Public Health 17 (2046). ISSN: 16604601. doi: 10.3390/ijerph17062046.

Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice

de Jesus D.F., Orime K., Kaminska D., Kimura T., Basile G., Wang C.H., Haertle L., Riemens R., Brown N.K., Hu J., Männistö V., Silva A.M., Dirice E., Tseng Y.H., Haaf T., Pihlajamäki J., Kulkarni R.N., (2020) Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice Journal of Clinical Investigation 130 :2391-2404. ISSN: 15588238. doi: 10.1172/JCI127502.

Perillaldehyde 1,2-epoxide loaded SLN-tailored mAb: Production, physicochemical characterization and in vitro cytotoxicity profile in MCF-7 cell lines

Souto E.B., Souto S.B., Zielinska A., Durazzo A., Lucarini M., Santini A., Horbańczuk O.K., Atanasov A.G., Marques C., Andrade L.N., Silva A.M., Severino P., (2020) Perillaldehyde 1,2-epoxide loaded SLN-tailored mAb: Production, physicochemical characterization and in vitro cytotoxicity profile in MCF-7 cell lines Pharmaceutics 12 (161). ISSN: 19994923. doi: 10.3390/pharmaceutics12020161.

Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

Zielinska A., Carreiró F., Oliveira A.M., Neves A., Pires B., Nagasamy Venkatesh D., Durazzo A., Lucarini M., Eder P., Silva A.M., Santini A., Souto E.B., (2020) Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology Molecules 25 (3731). ISSN: 14203049. doi: 10.3390/molecules25163731.

Polyphenol composition and biological activity of Thymus citriodorus and Thymus vulgaris: Comparison with endemic Iberian Thymus species

Taghouti M., Martins-Gomes C., Félix L.M., Schäfer J., Santos J.A., Bunzel M., Nunes F.M., Silva A.M., (2020) Polyphenol composition and biological activity of Thymus citriodorus and Thymus vulgaris: Comparison with endemic Iberian Thymus species Food Chemistry 331 (127362). ISSN: 18737072. doi: 10.1016/j.foodchem.2020.127362.

Potential application of grape (Vitis vinifera L.) stem extracts in the cosmetic and pharmaceutical industries: Valorization of a by-product

Leal C., Gouvinhas I., Santos R.A., Rosa E., Silva A.M., Saavedra M.J., Barros A.I.R.N.A., (2020) Potential application of grape (Vitis vinifera L.) stem extracts in the cosmetic and pharmaceutical industries: Valorization of a by-product Industrial Crops and Products 154 (112675). doi: 10.1016/j.indcrop.2020.112675.

Quinoline-and benzoselenazole-derived unsymmetrical squaraine cyanine dyes: Design, synthesis, photophysicochemical features and light-triggerable antiproliferative effects against breast cancer cell lines

Lima E., Boto R.E., Ferreira D., Fernandes J.R., Almeida P., Ferreira L.F.V., Souto E.B., Silva A.M., Reis L.V., (2020) Quinoline-and benzoselenazole-derived unsymmetrical squaraine cyanine dyes: Design, synthesis, photophysicochemical features and light-triggerable antiproliferative effects against breast cancer cell lines Materials 13 (2646). ISSN: 19961944. doi: 10.3390/ma13112646.

Red and near-infrared absorbing dicyanomethylene squaraine cyanine dyes: Photophysicochemical properties and anti-tumor photosensitizing effects

Martins T.D., Lima E., Boto R.E., Ferreira D., Fernandes J.R., Almeida P., Ferreira L.F.V., Silva A.M., Reis L.V., (2020) Red and near-infrared absorbing dicyanomethylene squaraine cyanine dyes: Photophysicochemical properties and anti-tumor photosensitizing effects Materials 13 (2083). ISSN: 19961944. doi: 10.3390/ma13092083.

Sage species case study on a spontaneous mediterranean plant to control phytopathogenic fungi and bacteria

Zaccardelli M., Pane C., Caputo M., Durazzo A., Lucarini M., Silva A.M., Severino P., Souto E.B., Santini A., De Feo V., (2020) Sage species case study on a spontaneous mediterranean plant to control phytopathogenic fungi and bacteria Forests 11 (704) :1-20. ISSN: 19994907. doi: 10.3390/f11060704.

Sucupira oil-loaded nanostructured lipid carriers (NLC): Lipid screening, factorial design, release profile, and cytotoxicity

Vieira R., Severino P., Nalone L.A., Souto S.B., Silva A.M., Lucarini M., Durazzo A., Santini A., Souto E.B., (2020) Sucupira oil-loaded nanostructured lipid carriers (NLC): Lipid screening, factorial design, release profile, and cytotoxicity Molecules 25 (685). ISSN: 14203049. doi: 10.3390/molecules25030685.

The nutraceutical value of carnitine and its use in dietary supplements

Durazzo A., Lucarini M., Nazhand A., Souto S.B., Silva A.M., Severino P., Souto E.B., Santini A., (2020) The nutraceutical value of carnitine and its use in dietary supplements Molecules 25 (molecules25092127). ISSN: 14203049. doi: 10.3390/molecules25092127.

Thymus zygis subsp. zygis an endemic portuguese plant: Phytochemical profiling, antioxidant, anti-proliferative and anti-inflammatory activities

Silva A.M., Martins-Gomes C., Souto E.B., Schäfer J., Santos J.A., Bunzel M., Nunes F.M., (2020) Thymus zygis subsp. zygis an endemic portuguese plant: Phytochemical profiling, antioxidant, anti-proliferative and anti-inflammatory activities Antioxidants 9 (482). ISSN: 20763921. doi: 10.3390/antiox9060482.

Two-and three-dimensional spectrofluorimetric qualitative analysis of selected vegetable oils for biomedical applications

Zielińska A., Kubasiewicz K., Wójcicki K., Silva A.M., Nunes F.M., Szalata M., Słomski R., Eder P., Souto E.B., (2020) Two-and three-dimensional spectrofluorimetric qualitative analysis of selected vegetable oils for biomedical applications Molecules 25 (5608). ISSN: 14203049. doi: 10.3390/molecules25235608.

Vitex agnus-castus l.: Main features and nutraceutical perspectives

Souto E.B., Durazzo A., Nazhand A., Lucarini M., Zaccardelli M., Souto S.B., Silva A.M., Severino P., Novellino E., Santini A., (2020) Vitex agnus-castus l.: Main features and nutraceutical perspectives Forests 11 (761). ISSN: 19994907. doi: 10.3390/f11070761.

3D printing in the design of pharmaceutical dosage forms

Souto E.B., Campos J.C., Filho S.C., Teixeira M.C., Martins-Gomes C., Zielinska A., Carbone C., Silva A.M., (2019) 3D printing in the design of pharmaceutical dosage forms Pharmaceutical Development and Technology 24 :1044-1053. ISSN: 10979867. doi: 10.1080/10837450.2019.1630426.

Cationic surfactants: Self-assembly, structure-activity correlation and their biological applications

Zakharova L.Y., Pashirova T.N., Doktorovova S., Fernandes A.R., Sanchez-Lopez E., Silva A.M., Souto S.B., Souto E.B., (2019) Cationic surfactants: Self-assembly, structure-activity correlation and their biological applications International Journal of Molecular Sciences 20 (5534). ISSN: 14220067. doi: 10.3390/ijms20225534.

Clotrimazole-loaded mediterranean essential oils NLC: A synergic treatment of Candida skin infections

Carbone C., Teixeira M.D.C., Sousa M.D.C., Martins-Gomes C., Silva A.M., Souto E.M.B., Musumeci T., (2019) Clotrimazole-loaded mediterranean essential oils NLC: A synergic treatment of Candida skin infections Pharmaceutics 11 (231). ISSN: 19994923. doi: 10.3390/pharmaceutics11050231.

Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines

Silva A.M., Martins-Gomes C., Fangueiro J.F., Andreani T., Souto E.B., (2019) Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines Pharmaceutical Development and Technology 24 :1243-1249. ISSN: 10979867. doi: 10.1080/10837450.2019.1658774.

Development and optimization of alpha-pinene-loaded solid lipid nanoparticles (SLN) using experimental factorial design and dispersion analysis

Zielinska A., Ferreira N.R., Durazzo A., Lucarini M., Cicero N., El Mamouni S., Silva A.M., Nowak I., Santini A., Souto E.B., (2019) Development and optimization of alpha-pinene-loaded solid lipid nanoparticles (SLN) using experimental factorial design and dispersion analysis Molecules 24 (2683). ISSN: 14203049. doi: 10.3390/molecules24152683.

Ginkgo biloba L. Leaf extract protects HepG2 cells against paraquat-induced oxidative DNA damage

Silva A.M., Silva S.C., Soares J.P., Martins-Gomes C., Teixeira J.P., Leal F., Gaivão I., (2019) Ginkgo biloba L. Leaf extract protects HepG2 cells against paraquat-induced oxidative DNA damage Plants 8 (556). ISSN: 22237747. doi: 10.3390/plants8120556.

In vitro cytotoxicity of oleanolic/ursolic acids-loaded in PLGA nanoparticles in different cell lines

Silva A.M., Alvarado H.L., Abrego G., Martins-Gomes C., Garduño-Ramirez M.L., García M.L., Calpena A.C., Souto E.B., (2019) In vitro cytotoxicity of oleanolic/ursolic acids-loaded in PLGA nanoparticles in different cell lines Pharmaceutics 11 (362). ISSN: 19994923. doi: 10.3390/pharmaceutics11080362.

Key production parameters for the development of solid lipid nanoparticles by high shear homogenization

Souto E., Doktorovova S., Zielinska A., Silva A., (2019) Key production parameters for the development of solid lipid nanoparticles by high shear homogenization Pharmaceutical Development and Technology 24 :1181-1185. ISSN: 10979867. doi: 10.1080/10837450.2019.1647235.

Meglumine-based supra-amphiphile self-assembled in water as a skin drug delivery system: Influence of unfrozen bound water in the system bioadhesiveness

de Souza A.L.R., Fonseca M., Ferreira L.M.B., Kurokawa S.S.S., Kiill C.P., Ferreira N.N., dos Santos Pyrrho A., Sarmento V.H.V., Silva A.M., Gremião M.P.D., Ribeiro C.A., (2019) Meglumine-based supra-amphiphile self-assembled in water as a skin drug delivery system: Influence of unfrozen bound water in the system bioadhesiveness Colloids and Surfaces B: Biointerfaces 184 (110523). ISSN: 18734367. doi: 10.1016/j.colsurfb.2019.110523.

Microemulsions: Principles, Scope, Methods, and Applications in Transdermal Drug Delivery.

Pereira, Irina; Antunes, Sara; Santos,Ana C.; Veiga, Francisco J.; Silva, Amélia M.; Boonme, Prapaporn; Souto, Eliana B. (2019) Microemulsions: Principles, Scope, Methods, and Applications in Transdermal Drug Delivery. In: Deepak Kumar Verma, Megh R. Goyal, Hafiz Anasr Rasul Suleria (Eds). Nanotechnology and Nanomaterial Applications in Food, Health and Biomedical Sciences”, PART I: NANOTECHNOLOGY TECHNIQUE (Chapter 2) :91-118. ISBN: 9781771887649.

Myasthenia gravis: State of the art and new therapeutic strategies

Souto E.B., Lima B., Campos J.R., Martins-Gomes C., Souto S.B., Silva A.M., (2019) Myasthenia gravis: State of the art and new therapeutic strategies Journal of Neuroimmunology 337 (577080). ISSN: 18728421. doi: 10.1016/j.jneuroim.2019.577080.

Nanoparticle delivery systems in the treatment of diabetes complications

Souto E.B., Souto S.B., Campos J.R., Severino P., Pashirova T.N., Zakharova L.Y., Silva A.M., Durazzo A., Lucarini M., Izzo A.A., Santini A., (2019) Nanoparticle delivery systems in the treatment of diabetes complications Molecules 24 (4209). ISSN: 14203049. doi: 10.3390/molecules24234209.

Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human Colon adenocarcinoma cell line

Campos J.R., Fernandes A.R., Sousa R., Fangueiro J.F., Boonme P., Garcia M.L., Silva A.M., Naveros B.C., Souto E.B., (2019) Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human Colon adenocarcinoma cell line Pharmaceutical Development and Technology 24 :616-622. ISSN: 10979867. doi: 10.1080/10837450.2018.1549075.

Photophysicochemical properties and in vitro phototherapeutic effects of iodoquinoline- and benzothiazole-derived unsymmetrical squaraine cyanine dyes

Friães S., Lima E., Boto R.E., Ferreira D., Fernandes J.R., Ferreira L.F.V., Silva A.M., Reis L.V., (2019) Photophysicochemical properties and in vitro phototherapeutic effects of iodoquinoline- and benzothiazole-derived unsymmetrical squaraine cyanine dyes Applied Sciences (Switzerland) 9 (5414). ISSN: 20763417. doi: 10.3390/app9245414.

Polyphenols for skin cancer: Chemical properties, structure-related mechanisms of action and new delivery systems

Souto E., Sampaio A., Campos J., Martins-Gomes C., Aires A., Silva A., (2019) Polyphenols for skin cancer: Chemical properties, structure-related mechanisms of action and new delivery systems Studies in Natural Products Chemistry 63 :21-42. ISBN: 9780128179017. doi: 10.1016/B978-0-12-817901-7.00002-2.

Rosmarinic Acid: Sources, Bioactivities and Health Benefits.

Martins-Gomes, Carlos; Nunes, Fernando M.; Sampaio, Ana C.; Souto, Eliana B.; Silva, Amélia M. (2019) Rosmarinic Acid: Sources, Bioactivities and Health Benefits. IN: Ryan, Iman (Ed.) Phytochemicals: Plant Sources and Potential Health Benefits. Book Series: Plant Science Research and Practices. NovaScience Publishers, New York, USA (Chapter 4) :109-146. ISBN: 978-1-53615-478-8.

Soft cationic nanoparticles for drug delivery: Production and cytotoxicity of solid lipid nanoparticles (SLNs)

Silva A.M., Martins-Gomes C., Coutinho T.E., Fangueiro J.F., Sanchez-Lopez E., Pashirova T.N., Andreani T., Souto E.B., (2019) Soft cationic nanoparticles for drug delivery: Production and cytotoxicity of solid lipid nanoparticles (SLNs) Applied Sciences (Switzerland) 9 (4438). ISSN: 20763417. doi: 10.3390/app9204438.

Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome—review of classical and new compounds: Part-i

Vieira R., Souto S.B., Sánchez-López E., Machado A.L., Severino P., Jose S., Santini A., Fortuna A., García M.L., Silva A.M., Souto E.B., (2019) Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome—review of classical and new compounds: Part-i Pharmaceuticals 12 (152). ISSN: 14248247. doi: 10.3390/ph12040152.

Surface-tailored anti-HER2/neu-solid lipid nanoparticles for site-specific targeting MCF-7 and BT-474 breast cancer cells

Souto E.B., Doktorovova S., Campos J.R., Martins-Lopes P., Silva A.M., (2019) Surface-tailored anti-HER2/neu-solid lipid nanoparticles for site-specific targeting MCF-7 and BT-474 breast cancer cells European Journal of Pharmaceutical Sciences 128 :27-35. ISSN: 18790720. doi: 10.1016/j.ejps.2018.11.022.

The influence of polysaccharide coating on the physicochemical parameters and cytotoxicity of silica nanoparticles for hydrophilic biomolecules delivery

Andreani T., Fangueiro J., Severino P., de Souza A., Martins-Gomes C., Fernandes P., Calpena A., Gremião M., Souto E., Silva A., (2019) The influence of polysaccharide coating on the physicochemical parameters and cytotoxicity of silica nanoparticles for hydrophilic biomolecules delivery Nanomaterials 9 (1081). ISSN: 20794991. doi: 10.3390/nano9081081.

Therapeutic interventions for countering leishmaniasis and chagas’s disease: From traditional sources to nanotechnological systems

Souto E.B., Dias-Ferreira J., Craveiro S.A., Severino P., Sanchez-Lopez E., Garcia M.L., Silva A.M., Souto S.B., Mahant S., (2019) Therapeutic interventions for countering leishmaniasis and chagas’s disease: From traditional sources to nanotechnological systems Pathogens 8 (119). ISSN: 20760817. doi: 10.3390/pathogens8030119.

Thymus carnosus extracts induce anti-proliferative activity in Caco-2 cells through mechanisms that involve cell cycle arrest and apoptosis

Martins-Gomes C., Souto E.B., Cosme F., Nunes F.M., Silva A.M., (2019) Thymus carnosus extracts induce anti-proliferative activity in Caco-2 cells through mechanisms that involve cell cycle arrest and apoptosis Journal of Functional Foods 54 :128-135. doi: 10.1016/j.jff.2019.01.010.

Trends in atopic dermatitis—from standard pharmacotherapy to novel drug delivery systems

Souto E.B., Dias-Ferreira J., Oliveira J., Sanchez-Lopez E., Lopez-Machado A., Espina M., Garcia M.L., Souto S.B., Martins-Gomes C., Silva A.M., (2019) Trends in atopic dermatitis—from standard pharmacotherapy to novel drug delivery systems International Journal of Molecular Sciences 20 (5659). ISSN: 14220067. doi: 10.3390/ijms20225659.

Uveal melanoma: physiopathology and new in situ-specific therapies

Souto E.B., Zielinska A., Luis M., Carbone C., Martins-Gomes C., Souto S.B., Silva A.M., (2019) Uveal melanoma: physiopathology and new in situ-specific therapies Cancer Chemotherapy and Pharmacology 84 :15-32. ISSN: 14320843. doi: 10.1007/s00280-019-03860-z.

Anti-inflammatory and Anti-cancer Activity of Citral: Optimization of Citral-loaded Solid Lipid Nanoparticles (SLN) using Experimental Factorial Design and LUMiSizer.

Zielińska, Alexandra; Martins-Gomes, Carlos; Ferreira, Nuno R. ; Silva, Amélia M.; Nowak, I.; Souto, Eliana B. (2018) Anti-inflammatory and Anti-cancer Activity of Citral: Optimization of Citral-loaded Solid Lipid Nanoparticles (SLN) using Experimental Factorial Design and LUMiSizer. INTERNATIONAL JOURNAL OF PHARMACEUTICS 553 (2-Jan) :428-440. doi: 10.1016/j.ijpharm.2018.10.065. (Impact factor, Quartile: 3.862, Q1).

Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss.

Martins-Gomes, Carlos; Taghouti, Meriem; Schaefer, Judith; Bunzel, Mirko; Silva, Amelia M.; Nunes, Fernando M. (2018) Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss. Journal Of Functional Foods 43 :154-164. doi: 10.1016/j.jff.2018.02.012. (Impact factor, Quartile: 3.47, Q1).

Citrus reticulata Blanco peels as a source of antioxidant and anti-proliferative phenolic compounds.

Ferreira, Sandrine S.; Silva, Amelia M.; Nunes, Fernando M. (2018) Citrus reticulata Blanco peels as a source of antioxidant and anti-proliferative phenolic compounds. Industrial Crops And Products 111 :141-148. doi: 10.1016/j.indcrop.2017.10.009. (Impact factor, Quartile: 3.849, Q1).

Hansen solubility parameters (HSP) for prescreening formulation of solid lipid nanoparticles (SLN): in vitro testing of curcumin-loaded SLN in MCF-7 and BT-474 cell lines.

Doktorovova, Slavomira; Souto, Eliana B.; Silva, Amelia M. (2018) Hansen solubility parameters (HSP) for prescreening formulation of solid lipid nanoparticles (SLN): in vitro testing of curcumin-loaded SLN in MCF-7 and BT-474 cell lines. Pharmaceutical Development And Technology 23 (1) :96-105. doi: 10.1080/10837450.2017.1384491. (Impact factor, Quartile: 1.945, Q3).

Linalool Bioactive Properties and Potential Applicability in Drug Delivery Systems.

Pereira, I.; Severino, Patrícia; Santos, Ana C.; Silva, Amélia M.; Souto, Eliana B. (2018) Linalool Bioactive Properties and Potential Applicability in Drug Delivery Systems. Colloids And Surfaces B-Biointerfaces 171 :566-578. doi: 10.1016/j.colsurfb.2018.08.001. (Impact factor, Quartile: 3.997, Q1).

Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles.

Carbone, C.; Martins-Gomes, C.; Caddeo, C.; Silva, A. M.; Musumeci, T.; Pignatello, R.; Puglisi, G.; Souto, E. B. (2018) Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles. International Journal Of Pharmaceutics 548 (1) :217-226. doi: 10.1016/j.ijpharm.2018.06.064. (Impact factor, Quartile: 3.862, Q1).

Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization.

Sanchez-Lopez, Elena; Ettcheto, Miren; Antonia Egea, Maria; Espina, Marta; Cano, Amanda; Cristina Calpena, Ana; Camins, Antoni; Carmona, Nuria; Silva, Amelia M.; Souto, Eliana B.; Luisa Garcia, Maria (2018) Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization. Journal Of Nanobiotechnology 16. doi: 10.1186/s12951-018-0356-z. (Impact factor, Quartile: 5.294, Q1).

Memantine-Loaded PEGylated Biodegradable Nanoparticles for the Treatment of Glaucoma.

Sanchez-Lopez, Elena; Antonia Egea, Maria; Davis, Benjamin Michael; Guo, Li; Espina, Marta; Silva, Amelia Maria; Cristina Calpena, Ana; Barbosa Souto, Eliana Maria; Ravindran, Nivedita; Ettcheto, Miren; Camins, Antonio; Luisa Garcia, Maria; Cordeiro, Maria Francesca (2018) Memantine-Loaded PEGylated Biodegradable Nanoparticles for the Treatment of Glaucoma. Small 14 (2). doi: 10.1002/smll.201701808. (Impact factor, Quartile: 9.598, Q1).

Optimization of Linalool-loaded Solid Lipid Nanoparticles using Experimental Factorial Design and Long-term Stability Studies with a New Centrifugal Sedimentation Method.

Pereira, I.; Alexandra Zielińska; Nuno R. Ferreira; Amélia M. Silva; Eliana B. Souto (2018) Optimization of Linalool-loaded Solid Lipid Nanoparticles using Experimental Factorial Design and Long-term Stability Studies with a New Centrifugal Sedimentation Method. International Journal Of Pharmaceutics 549 (1) :261-270. doi: 10.1016/j.ijpharm.2018.07.068. (Impact factor, Quartile: 3.862, Q1).

Optimization, Biopharmaceutical Profile and Therapeutic Efficacy of Pioglitazone-loaded PLGA-PEG Nanospheres as a Novel Strategy for Ocular Inflammatory Disorders.

Silva-Abreu, Marcelle; Cristina Calpena, Ana; Espina, Marta; Silva, Amelia M.; Gimeno, Alvaro; Antonia Egea, Maria; Luisa Garcia, Maria (2018) Optimization, Biopharmaceutical Profile and Therapeutic Efficacy of Pioglitazone-loaded PLGA-PEG Nanospheres as a Novel Strategy for Ocular Inflammatory Disorders. Pharmaceutical Research 35 (1). doi: 10.1007/s11095-017-2319-8. (Impact factor, Quartile: 3.335, Q2).

Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy.

Carbone, C.; Martins-Gomes, C.; Pepe, V.; Silva, A. M.; Musumeci, T.; Puglisi, G.; Furneri, P. M.; Souto, E. B. (2018) Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy. Colloids And Surfaces B-Biointerfaces 167 :337-344. doi: 10.1016/j.colsurfb.2018.04.031. (Impact factor, Quartile: 3.997, Q1).

Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds.

Taghouti, Meriem; Martins-Gomes, Carlos; Schaefer, Judith; Felix, Luis M.; Santos, Joao A.; Bunzel, Mirko; Nunes, Fernando M.; Silva, Amelia M. (2018) Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds. Food & Function 9 (7) :3617-3629. doi: 10.1039/c8fo00456k. (Impact factor, Quartile: 3.289, Q1).

Titanium dioxide nanoparticles: Toxicity and genotoxicity in Drosophila melanogaster (SMART eye-spot test and comet assay in neuroblasts).

Sario, Sara; Silva, Amelia M.; Gaivao, Isabel (2018) Titanium dioxide nanoparticles: Toxicity and genotoxicity in Drosophila melanogaster (SMART eye-spot test and comet assay in neuroblasts). Mutation Research-Genetic Toxicology And Environmental Mutagenesis 831 :19-23. doi: 10.1016/j.mrgentox.2018.05.001. (Impact factor, Quartile: 1.996, Q3).

Influence of the stabilizers on the toxicity of metallic nanomaterials in aquatic organisms and human cell lines.

Researchers / Amélia Silva